Thrombopoietin measurement in thrombocytosis: dysregulation and lack of feedback inhibition in essential thrombocythaemia
In: British journal of haematology, Jg. 99 (1998-01-31), Heft 4
Online
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Zugriff:
Essential thrombocythaemia (ET), a myeloproliferative disorder (MPD) manifested by excessive platelet production, lacks a specific diagnostic test to facilitate differentiation from other thrombocytoses. We studied thrombopoietin (TPO) levels in 41 patients with thrombocytosis: 25 ET patients, eight with other MPD, and eight with reactive thrombocytosis. Mean age and platelet counts for these groups were comparable. TPO levels for 96 healthy individuals provided a reference range for normal. The majority of ET patients (19/25 or 76%) had normal TPO levels. No patient with ET had a TPO level below 75 pg/ml, compared with 57% of healthy donors and 8/16 (50%) patients with other thrombocytoses (P
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Thrombopoietin measurement in thrombocytosis: dysregulation and lack of feedback inhibition in essential thrombocythaemia
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Autor/in / Beteiligte Person: | Rodwell, R. ; Taylor, Kerry ; Taylor, D. ; Moore, D. ; Pitcher, L. ; Marty, J. ; Wright, S. ; Nichol, Janet L. ; Rentoul, A. ; Selsi, D. ; Kelly, C. |
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Zeitschrift: | British journal of haematology, Jg. 99 (1998-01-31), Heft 4 |
Veröffentlichung: | 1998 |
Medientyp: | unknown |
ISSN: | 0007-1048 (print) |
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