Chemical Characterization and Biological Activity of the Mastic Gum Essential Oils of Pistacia lentiscus Var. Chia from Turkey
In: Molecules, Jg. 25 (2020-05-02), Heft 2136, p 2136
Online
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Zugriff:
The essential oils (EOs) were isolated by hydrodistillation from wild and cultivated Pistacia lentiscus L. var. chia&mdash
mastic gum tree (Anacardiaceae) from two natural habitats, namely from Cesme&ndash
Uzunkoy (1) and Mordogan (2), and one cultivated source, Cesme&ndash
Germiyan (3), in Izmir, Turkey. This comparative study evaluated the chemical composition and biological activity of mastic gum essential oils (MGEOs). For this purpose, MGEOs 1&ndash
3 were analyzed by gas chromatography&ndash
flame ionization detection (GC-FID), gas chromatography&ndash
mass spectrometry (GC-MS), and chiral GC for &alpha
pinene. Laboratory assays were conducted to assess for potential in vitro cytotoxicity (multiple in vitro cancer cell lines), antimicrobial properties (five bacterial species and yeast), anti-inflammatory activity (inhibition of inducible nitric oxide synthase, iNOS), and the attraction of Ceratitis capitata (Mediterranean fruit fly, medfly), respectively. Chemical analysis indicated that MGEOs 1 and 2 were rich in &alpha
pinene (56.2% and 51.9%), myrcene (20.1% and 18.6%), and &beta
pinene (2.7% and 3.1%), respectively
whereas MGEO-3 was characterized by a high level of &alpha
pinene (70.8%), followed by &beta
pinene (5.7%) and myrcene (2.5%). Chiral GC analyses showed that concentration ratios between (&minus
)/(+)-&alpha
pinene and (&minus
)-&alpha
pinene/myrcene allowed for differentiation between wild and cultivated MGEO sources. In biological assays, MGEOs 1&ndash
3 did not exhibit significant antimicrobial effects against the pathogens evaluated and were not strong attractants of male medflies
however, all three MGEOs displayed a dose-dependent inhibition of iNOS, and MGEOs 1 and 2 exhibited selective in vitro cytotoxicity against human cancer cells. These results suggest that wild-type mastic gum oils from Cesme and Mordogan (MGEOs 1 and 2) are potential sources of beneficial products and warrant further investigation.
| Titel: |
Chemical Characterization and Biological Activity of the Mastic Gum Essential Oils of Pistacia lentiscus Var. Chia from Turkey
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| Autor/in / Beteiligte Person: | Nalbantsoy, Ayse ; Demirci, Betül ; Demirci, Fatih ; Tabanca, Nurhayat ; Kendra, Paul E. ; Üniversitesi, Ege ; Üniversitesi, Anadolu |
| Link: | |
| Zeitschrift: | Molecules, Jg. 25 (2020-05-02), Heft 2136, p 2136 |
| Veröffentlichung: | Multidisciplinary Digital Publishing Institute, 2020 |
| Medientyp: | unknown |
| ISSN: | 1420-3049 (print) |
| DOI: | 10.3390/molecules25092136 |
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