Acute and sustained changes in sodium balance during nifedipine treatment in essential hypertension
In: The American journal of medicine, Jg. 91 (1991-09-01), Heft 3
Online
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Zugriff:
purpose: To assess the changes in sodium excretion and sodium balance after initiation of nifedipine treatment and after withdrawal of nifedipine. patients: Eight patients with uncomplicated mild to moderate essential hypertension were entered in a single-blind, placebo-controlled study of 39 days' duration. methods: Two 7-day periods while on a fixed sodium intake of 150 mmol/day approximately 3 weeks apart. After 4 days of a placebo and fixed sodium intake, patients were given nifedipine GITS (gastrointestinal therapeutic system) once a day and carefully studied for the following 4 days. Thereafter, patients continued to receive nifedipine GITS, and approximately 3 weeks later they were studied again for a week while on a fixed sodium intake. Nifedipine administration was stopped and changes occurring after withdrawal were studied. results: Nifedipine caused a significant increase in sodium excretion with a cumulative loss of sodium of 38 mmol per subject within the first 4 days of treatment. The withdrawal of nifedipine treatment caused a significant decrease in sodium excretion and a cumulative retention of sodium of 42 mmol per subject within the first 4 days of withdrawal. conclusions: Nifedipine causes an acute and a sustained reduction in sodium balance in patients with essential hypertension. This prolonged effect may contribute to the mechanism whereby nifedipine lowers blood pressure.
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Acute and sustained changes in sodium balance during nifedipine treatment in essential hypertension
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Autor/in / Beteiligte Person: | Singer, Donald R. J. ; Markandu, Nirmala D. ; Cappuccio, Francesco P. ; MacGregor, Graham A. ; Sagnella, Giuseppe A. ; Miller, Michelle A. ; Buckley, M. G. |
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Zeitschrift: | The American journal of medicine, Jg. 91 (1991-09-01), Heft 3 |
Veröffentlichung: | 1991 |
Medientyp: | unknown |
ISSN: | 0002-9343 (print) |
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