A clinical-molecular prognostic model to predict survival in patients with post polycythemia vera and post essential thrombocythemia myelofibrosis
In: Leukemia, Jg. 31 (2017-02-08), Heft 12
Online
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Zugriff:
Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms with variable risk of evolution into post-PV and post-ET myelofibrosis, from now on referred to as secondary myelofibrosis (SMF). No specific tools have been defined for risk stratification in SMF. To develop a prognostic model for predicting survival, we studied 685 JAK2, CALR, and MPL annotated patients with SMF. Median survival of the whole cohort was 9.3 years (95% CI: 8-not reached-NR-). Through penalized Cox regressions we identified negative predictors of survival and according to beta risk coefficients we assigned 2 points to hemoglobin level
| Titel: |
A clinical-molecular prognostic model to predict survival in patients with post polycythemia vera and post essential thrombocythemia myelofibrosis
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| Autor/in / Beteiligte Person: | Caramella, Marianna ; Benevolo, Giulia ; Maffioli, Margherita ; Palandri, Francesca ; Guglielmelli, Paola ; Caramazza, Domenica ; Albano, Francesco ; Komrokji, Rami S. ; Barbui, T ; V. De Stefano ; J J Kiladjian ; Giorgino, Toni ; Ruggeri, Marco ; Gotlib, Jason ; Silver, Richard T. ; Casalone, Rosario ; Devos, Timothy ; Vannucchi, Alessandro M. ; Cazzola, Mario ; Mora, Barbara ; Passamonti, Francesco ; Rumi, Elisa ; Rotunno, Giada ; Pietra, Daniela ; Cervantes, Francisco ; Merli, Michele ; Rambaldi, Alessandro |
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| Zeitschrift: | Leukemia, Jg. 31 (2017-02-08), Heft 12 |
| Veröffentlichung: | 2017 |
| Medientyp: | unknown |
| ISSN: | 1476-5551 (print) |
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