Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry
In: Nature Communications, Jg. 14 (2023-03-31)
Online
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Zugriff:
Human parechovirus (PeV-A) is an RNA virus that belongs to the family Picornaviridae and it is currently classified into 19 genotypes. PeV-As usually cause mild illness in children and adults. Among the genotypes, PeV-A3 can cause severe diseases in neonates and young infants, resulting in neurological sequelae and death. In this study, we identify the human myeloid-associated differentiation marker (MYADM) as an essential host factor for the entry of six PeV-As (PeV-A1 to PeV-A6), including PeV-A3. The infection of six PeV-As (PeV-A1 to PeV-A6) to human cells is abolished by knocking out the expression of MYADM. Hamster BHK-21 cells are resistant to PeV-A infection, but the expression of human MYADM in BHK-21 confers PeV-A infection and viral production. Furthermore, VP0 capsid protein of PeV-A3 interacts with one extracellular domain of human MYADM on the cell membrane of BHK-21. The identification of MYADM as an essential entry factor for PeV-As infection is expected to advance our understanding of the pathogenesis of PeV-As.
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Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry
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Autor/in / Beteiligte Person: | Watanabe, Kanako ; Oka, Tomoichiro ; Takagi, Hirotaka ; Anisimov, Sergei ; Yamashita, Shun-ichi ; Katsuragi, Yoshinori ; Takahashi, Masahiko ; Higuchi, Masaya ; Kanki, Tomotake ; Saitoh, Akihiko ; Fujii, Masahiro |
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Zeitschrift: | Nature Communications, Jg. 14 (2023-03-31) |
Veröffentlichung: | Springer Science and Business Media LLC, 2023 |
Medientyp: | unknown |
ISSN: | 2041-1723 (print) |
DOI: | 10.1038/s41467-023-37399-8 |
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