An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
In: Science, Jg. 274 (1996-11-01), S. 782-784
Online
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Zugriff:
Studies on mice deficient in nuclear factor kappa B (NF-κB) subunits have shown that this transcription factor is important for lymphocyte responses to antigens and cytokine-inducible gene expression. In particular, the RelA (p65) subunit is required for induction of tumor necrosis factor-α (TNF-α)-dependent genes. Treatment of RelA-deficient (RelA−/−) mouse fibroblasts and macrophages with TNF-α resulted in a significant reduction in viability, whereas RelA+/+ cells were unaffected. Cytotoxicity to both cell types was mediated by TNF receptor 1. Reintroduction of RelA into RelA−/− fibroblasts resulted in enhanced survival, demonstrating that the presence of RelA is required for protection from TNF-α. These results have implications for the treatment of inflammatory and proliferative diseases.
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An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
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Autor/in / Beteiligte Person: | Baltimore, David ; Beg, Amer A. |
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Zeitschrift: | Science, Jg. 274 (1996-11-01), S. 782-784 |
Veröffentlichung: | American Association for the Advancement of Science (AAAS), 1996 |
Medientyp: | unknown |
ISSN: | 1095-9203 (print) ; 0036-8075 (print) |
DOI: | 10.1126/science.274.5288.782 |
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