A Possible Role of Arachidonic Acid Metabolites in Essential Hypertension
In: Prostaglandins and the Kidney ISBN: 9781468442793; (1983)
Online
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Zugriff:
The level of arterial blood pressure is set by complex interactions of several mechanisms which influence both blood flow in and resistance of the vascular system. An imbalance which favors those that elevate vascular resistance or extracellular volume will result in hypertension. Such alterations may include increased activity of the adrenergic nervous system or the rennin—angiotensin system or excessive secretion of mineralocorticoids. Of equal importance may be a reduced activity of blood pressure-lowering factors, such as prostaglandins and the kallikrein—kinin system. A deficiency of the vasodepressor systems may lead to hypertension, even without an increase in the activity of the blood pressure-elevating systems. The contribution of prostaglandins for the development of hypertension and hypertensive vascular disease may be based on an inherent abnormality of the prostaglandin system, as well as on the effects of major risk factors such as dietary intake of sodium and fat on prostaglandin formation.
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A Possible Role of Arachidonic Acid Metabolites in Essential Hypertension
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Autor/in / Beteiligte Person: | Witzgall, H. ; Lorenz, R. ; Weber, P. C. ; Scherer, B. ; Siess, W. |
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Quelle: | Prostaglandins and the Kidney ISBN: 9781468442793; (1983) |
Veröffentlichung: | Springer US, 1983 |
Medientyp: | unknown |
ISBN: | 978-1-4684-4279-3 (print) |
DOI: | 10.1007/978-1-4684-4277-9_35 |
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