Chronobiologic Evaluation of Captopril-Retard Twice a Day in Essential Hypertension: In Comparison with Captopril Three Times a Day
In: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, Jg. 22 (1991), S. 641-649
Online
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Zugriff:
The purpose of this study was to evaluate the efficacy of captopril-retard (C-R) and captopril (C) chronobiologically in patients with essential hypertension. Doses of C-R of 18.75mg twice a day and C of 12.5-25mg three times a day were administered at least 6wk in each of 9 patients. The blood pressure (BP) monitoring was repeated before and after the treatment for 48hr every 30min with an ambulatory instrument (ABPM-630, Nippon Colin, Japan). These data were analyzed with conventional statistical and cosinor methods. The hyper- and hypobaric indices of BP were calculated based on our reference limits. The least square fit of a cosine curve with a period of 24hr was calculated to obtain a midline estimating statistic of rhythm (MESOR), amplitude, and acropase. A circadian rhythm cycle of about 24hr was found in the BP in all cases. C-R lowered MESOR of systolic BP (SBP) and diastolic BP (DBP) from 134.6±9.7mmHg to 129.9±9.9mmHg and 77.4±4.3mmHg to 70.2±5.7mmHg (P
| Titel: |
Chronobiologic Evaluation of Captopril-Retard Twice a Day in Essential Hypertension: In Comparison with Captopril Three Times a Day
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| Autor/in / Beteiligte Person: | Saito, Yuzo ; Sawanobori, Takao ; Mukaiyama, Shigeo ; Kohno, Isao ; Iwasaki, Koichi ; Ishii, Hiroyuki ; Ijiri, Hiroshi ; Komaya, Takao ; Nakamura, Takamichi ; Tsuruta, Ikuo ; Tamura, Kohji |
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| Zeitschrift: | Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, Jg. 22 (1991), S. 641-649 |
| Veröffentlichung: | Japanese Society of Clinical Pharmacology and Therapeutics, 1991 |
| Medientyp: | unknown |
| ISSN: | 1882-8272 (print) ; 0388-1601 (print) |
| DOI: | 10.3999/jscpt.22.641 |
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