Mitochondria Play an Essential Role in Heart Failure
In: Mitochondria and Their Role in Cardiovascular Disease ISBN: 9781461445982; (2012-10-11)
Online
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Zugriff:
Both clinical studies and animal models have shown that mitochondria are at the center of the pathophysiology and pathogenesis of the failing heart since mitochondrial-based oxidative stress together with cell death and cardiac bioenergetic dysfunction is profoundly implicated in the progression of heart failure (HF). The evidence available on the role that mitochondrial defects play in the development of HF and potential new approaches to therapeutic targeting of mitochondrial bioenergetic, biogenetic, and signaling abnormalities will be discussed in this chapter.
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Mitochondria Play an Essential Role in Heart Failure
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Autor/in / Beteiligte Person: | Marín-García, José |
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Quelle: | Mitochondria and Their Role in Cardiovascular Disease ISBN: 9781461445982; (2012-10-11) |
Veröffentlichung: | Springer US, 2012 |
Medientyp: | unknown |
ISBN: | 978-1-4614-4598-2 (print) |
DOI: | 10.1007/978-1-4614-4599-9_18 |
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