Penetration-Enhancing Effect of the Essential Oil and Methanolic Extract ofEryngium bungeion Percutaneous Absorption of Piroxicam through Rat Skin
In: Journal of Essential Oil Bearing Plants, Jg. 12 (2009), S. 728-741
Online
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Zugriff:
Recently, in order to improve drug permeation through the skin, penetration enhancers have attracted a great deal of interest in increasing percutaneous absorption. Natural compounds like terpenes have been suggested as promising non-toxic, non-irritating transdermal penetration enhancers. This investigation aimed to study the effect of extract and essential oil of Eryngium bungei (as a traditional anti-inflammatory and antinociceptive) on the transdermal absorption of piroxicam. The stable gel was chosen and enhancing effects of plant extract and essential oil with different concentrations (0.5 - 3.0 and 0.25 - 5.0 % w/w respectively) on the permeation of piroxicam were evaluated. The results showed that the greatest enhancement of the skin transport occurs at the highest concentration of the enhancer (P < 0.01). The most outstanding penetration enhancer was plant essential oil in 5 % w/w, providing an almost 9.17-fold increase in permeability coefficient of piroxicam.
Titel: |
Penetration-Enhancing Effect of the Essential Oil and Methanolic Extract ofEryngium bungeion Percutaneous Absorption of Piroxicam through Rat Skin
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Autor/in / Beteiligte Person: | Saeedi, Majid ; Morteza-Semnani, Katayoun |
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Zeitschrift: | Journal of Essential Oil Bearing Plants, Jg. 12 (2009), S. 728-741 |
Veröffentlichung: | Informa UK Limited, 2009 |
Medientyp: | unknown |
ISSN: | 0976-5026 (print) ; 0972-060X (print) |
DOI: | 10.1080/0972060x.2009.10643782 |
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