Modulation of JAK2 V617F allele burden dynamics by hydroxycarbamide in polycythaemia vera and essential thrombocythaemia patients
In: British Journal of Haematology, Jg. 152 (2011-01-10), S. 413-419
Online
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Zugriff:
Summary The modulation of JAK2 V617F allele burden dynamics was prospectively analysed in 47 patients (26 polycythaemia vera [PV] and 21 essential thrombocythaemia [ET]) treated with first-line hydroxyurea (HU) and compared with the JAK2 V617F dynamics of a control group of 45 PV and ET patients. A partial molecular response (PMR), according to European Leukaemia Net criteria, was observed in 27/47 (57%) patients. Median time to PMR was 14 months (3–66) with a probability of PMR at 3 years of 57%. A significant decrease in JAK2 V617F allele load was observed at 36 months both in PV and ET patients, being the reduction in PV higher than in ET patients (P = 0·01). A haematocrit ≥0·45 L/L was associated with a higher probability of attaining a PMR (HR:3·4; 95%CI:1·02–11·6, P = 0·04). Control group showed a slight increase of JAK2 V617F allele burden over time. The reduction in the mutated allele load comparing treated patients versus controls was highly significant both in PV and ET, demonstrating a clear effect of HU on the JAK2 V617F allele burden. In conclusion, first-line HU can attain PMR in more than 50% of newly diagnosed PV and ET patients, with a continuous decrease of the JAK2 V617F allele burden in PV patients during treatment.
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Modulation of JAK2 V617F allele burden dynamics by hydroxycarbamide in polycythaemia vera and essential thrombocythaemia patients
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Autor/in / Beteiligte Person: | Besses, Carlos ; Alvarez-Larrán, Alberto ; Florensa, Lourdes ; Salar, Antonio ; Martínez-Avilés, Luz ; Longarón, Raquel ; Serrano, Sergi ; Mojal, Sergi ; Bellosillo, Beatriz |
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Zeitschrift: | British Journal of Haematology, Jg. 152 (2011-01-10), S. 413-419 |
Veröffentlichung: | Wiley, 2011 |
Medientyp: | unknown |
ISSN: | 0007-1048 (print) |
DOI: | 10.1111/j.1365-2141.2010.08467.x |
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