NMR Investigation on Melaleuca alternifolia Essential Oil Dispersed in the Monoolein Aqueous System: Phase Behavior and Dynamics
In: Langmuir, Jg. 18 (2002-09-13), S. 7916-7922
Online
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Zugriff:
The antiseptic, antibacterial, and antifungal properties of the essential oil of Melaleuca alternifolia, commonly called tea tree oil (TTO), are well-known. This mixture of monoterpenes, sesquiterpenes, and their alcohols is utilized in many therapeutic and cosmetic applications, directly as essential oil or in different kinds of formulations. The terpinen-4-ol, which is present in the commercial essential oil samples in the minimum amount of 30 wt %, is recognized as the main active agent of TTO. Considering the good performance of lipid-based liquid crystalline phases as drug delivery systems, the monoolein/water system has been assessed for both terpinen-4-ol and TTO formulations. The phase behavior of the ternary systems has been investigated by means of optical microscopy and 2H NMR quadrupolar splitting. 13C NMR spin−lattice relaxation times and self-diffusion coefficients (measured by 13C NMR PGSE technique) of the lipid matrix and the active agent have been determined to give insights on the dynam...
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NMR Investigation on Melaleuca alternifolia Essential Oil Dispersed in the Monoolein Aqueous System: Phase Behavior and Dynamics
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Autor/in / Beteiligte Person: | Lazzari, Paolo ; Monduzzi, Maura ; Caboi, Francesca ; Murgia, Sergio |
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Zeitschrift: | Langmuir, Jg. 18 (2002-09-13), S. 7916-7922 |
Veröffentlichung: | American Chemical Society (ACS), 2002 |
Medientyp: | unknown |
ISSN: | 1520-5827 (print) ; 0743-7463 (print) |
DOI: | 10.1021/la0259959 |
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