Osteopontin associated with left ventricular hypertrophy and diastolic dysfunction in essential hypertension
In: Journal of Human Hypertension, Jg. 34 (2019-09-02), S. 388-396
Online
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Zugriff:
To investigate the relationship between circulating osteopontin (OPN) and left ventricular (LV) geometry, as well as systolic and diastolic function in patients with essential hypertension. One hundred and ninety-nine essential hypertensive patients were recruited (mean age 62.5 ± 9.5, male 59%) in this study and were classified into two groups by the median of lg OPN: patients with lg OPN 0.975 (n = 99, 49.7%, high-OPN group). Patients in high-OPN group had higher left ventricular mass index (LVMI) than low-OPN group (112 ± 25 vs. 106 ± 19 g/m2, p = 0.045) and higher ratio of peak early to tissue Doppler early diastolic (E/e’: 11.5 ± 3.4 vs. 10.6 ± 2.5, p = 0.03). There was no difference in LV diameter, relative wall thickness, or LV ejection fraction between groups. The prevalence of left ventricular diastolic dysfunction (LVDD) was significantly greater in patients with high-OPN than low-OPN group (27% vs. 12%, P = 0.005). LVMI independently correlated to age (β = 0.239, p = 0.001), 24-h mean systolic blood pressure (β = 0.379, p
Titel: |
Osteopontin associated with left ventricular hypertrophy and diastolic dysfunction in essential hypertension
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Autor/in / Beteiligte Person: | Wang, Yan ; Yang, Yan ; Gao, Pingjin |
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Zeitschrift: | Journal of Human Hypertension, Jg. 34 (2019-09-02), S. 388-396 |
Veröffentlichung: | Springer Science and Business Media LLC, 2019 |
Medientyp: | unknown |
ISSN: | 1476-5527 (print) ; 0950-9240 (print) |
DOI: | 10.1038/s41371-019-0246-3 |
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