Chemical Composition and Antimycobacterial Activity of the Essential Oil from Anemia tomentosa var. anthriscifolia
In: Natural Product Communications, Jg. 4 (2009-12-01), S. 1934578X0900401
Online
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Zugriff:
The essential oil from Anemia tomentosa var. anthriscifolia showed in vitro activity against Mycobacterium tuberculosis (MIC 100 μg/ml) and therefore was characterized by gas chromatography (GC) and by gas chromatography coupled with mass spectrometry (GC-MS). The major constituents of this essential oil were triquinane sesquiterpenes: silphiperfol-6-ene (14.7%), (–)-epi-presilphiperfolan-1-ol (30.6%), presilphiperfol-7-ene (3.9%), cameroonan-7α-ol (4.4%), prenopsan-8-ol (1.9%) and presilphiperfolan-8-ol (8.3%), suggesting the existence of different chemotypes for this species. The essential oil was fractionated by column chromatography and its major constituent and fractions were assayed against Mycobacterium tuberculosis and M. smegmatis. (–)-epi-Presilphiperfolan-1-ol exhibited an MIC of 120 μg/ml against M. tuberculosis H37Rv.
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Chemical Composition and Antimycobacterial Activity of the Essential Oil from Anemia tomentosa var. anthriscifolia
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| Autor/in / Beteiligte Person: | Pedro Eduardo Almeida da Silva ; Daniela Fernandes Ramos ; Maria C.S. Lourenço ; Shaft Corrêa Pinto ; Gilda Guimarães Leitão ; Bizzo, Humberto R. ; Danilo Ribeiro de Oliveira ; Leitão, Suzana G. ; Coelho, Tatiane S. |
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| Zeitschrift: | Natural Product Communications, Jg. 4 (2009-12-01), S. 1934578X0900401 |
| Veröffentlichung: | SAGE Publications, 2009 |
| Medientyp: | unknown |
| ISSN: | 1555-9475 (print) ; 1934-578X (print) |
| DOI: | 10.1177/1934578x0900401213 |
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