The Protein Kinase p90 Rsk as an Essential Mediator of Cytostatic Factor Activity
In: Science, Jg. 286 (1999-11-12), S. 1362-1365
Online
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Zugriff:
Persistent activation of p42 mitogen-activated protein kinase (p42 MAPK) during mitosis induces a “cytostatic factor” arrest, the arrest responsible for preventing the parthenogenetic activation of unfertilized eggs. The protein kinase p90 Rsk is a substrate of p42 MAPK; thus, the role of p90 Rsk in p42 MAPK-induced mitotic arrest was examined. Xenopus laevis egg extracts immunodepleted of Rsk lost their capacity to undergo mitotic arrest in response to activation of the Mos–MEK-1–p42 MAPK cascade of protein kinases. Replenishing Rsk-depleted extracts with catalytically competent Rsk protein restored the ability of the extracts to undergo mitotic arrest. Rsk appears to be essential for cytostatic factor arrest.
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The Protein Kinase p90 Rsk as an Essential Mediator of Cytostatic Factor Activity
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Autor/in / Beteiligte Person: | Bhatt, Ramesh R. ; Ferrell, James E. |
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Zeitschrift: | Science, Jg. 286 (1999-11-12), S. 1362-1365 |
Veröffentlichung: | American Association for the Advancement of Science (AAAS), 1999 |
Medientyp: | unknown |
ISSN: | 1095-9203 (print) ; 0036-8075 (print) |
DOI: | 10.1126/science.286.5443.1362 |
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