Azelaic acid and Melaleuca alternifolia essential oil co-loaded vesicular carrier for combinational therapy of acne
In: Therapeutic Delivery, Jg. 13 (2022), S. 13-29
Online
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Zugriff:
Aim: Azelaic acid (AzA), a comedolytic, antibacterial, anti-inflammatory anti-melanogenic agent, prescribed against acne vulgaris is safe on skin. Its combination with another widely used anti-acne agent, tea tree oil (EO) whose delivery is limited by volatility, instability and lipophilicity constraints was attempted. Method: Solvent injection was used to prepare AzA-EO integrated ethosomes. Result: Ethosomes were transformed into carbopol hydrogel, which exhibited pseudo-plastic properties with appreciable firmness, work of shear, stickiness and work of adhesion. The hydrogel showed better permeation and retention characteristics vis-a-vis commercial formulation (AzidermTM), when evaluated in Wistar rat skin. Further, ethosome hydrogel composite was better tolerated with no side effects. Conclusion: The findings suggests that the aforementioned strategy could be a potential treatment used for acne management.
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Azelaic acid and Melaleuca alternifolia essential oil co-loaded vesicular carrier for combinational therapy of acne
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Autor/in / Beteiligte Person: | Hemrajani, Chetna ; Rolta, Rajan ; Bisht, Alpna ; Gupta, Gaurav ; Dev, Kamal ; Sourirajan, Anuradha ; Rathore, Charul ; Tambuwala, Murtaza M. ; Bakshi, Hamid A. ; Dinesh Kumar Chellappan ; Dua, Kamal ; Nidhi, Prakriti ; Navneet Kumar Upadhyay ; Aljabali, Alaa A. A. ; Negi, Poonam |
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Zeitschrift: | Therapeutic Delivery, Jg. 13 (2022), S. 13-29 |
Veröffentlichung: | Future Science Ltd, 2022 |
Medientyp: | unknown |
ISSN: | 2041-6008 (print) ; 2041-5990 (print) |
DOI: | 10.4155/tde-2021-0059 |
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