A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice
In: Science, Jg. 308 (2005-04-15), S. 411-413
Online
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Zugriff:
The Drosophila cuticle is essential for maintaining the surface barrier defenses of the fly. Integral to cuticle resilience is the transcription factor grainy head , which regulates production of the enzyme required for covalent cross-linking of the cuticular structural components. We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3 . Mice lacking this factor display defective skin barrier function and deficient wound repair, accompanied by reduced expression of transglutaminase 1, the key enzyme involved in cross-linking the structural components of the superficial epidermis. These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution.
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A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice
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Autor/in / Beteiligte Person: | Jane, Stephen M. ; Hislop, Nikki R. ; Cunningham, John M. ; Uchida, Yoshikazu ; Elias, Peter M. ; Auden, Alana ; Ting, Stephen B. ; Wilanowski, Tomasz ; Zhao, Lin-Lin ; Caddy, Jacinta ; Holleran, Walter M. ; Kaur, Pritinder ; Ellis, Sarah |
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Zeitschrift: | Science, Jg. 308 (2005-04-15), S. 411-413 |
Veröffentlichung: | American Association for the Advancement of Science (AAAS), 2005 |
Medientyp: | unknown |
ISSN: | 1095-9203 (print) ; 0036-8075 (print) |
DOI: | 10.1126/science.1107511 |
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