The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells
In: Nature Immunology, Jg. 16 (2015-06-29), S. 810-818
Online
unknown
Zugriff:
Foxm1 is known as a typical proliferation-associated transcription factor. Here we found that Foxm1 was essential for maintenance of the quiescence and self-renewal capacity of hematopoietic stem cells (HSCs) in vivo in mice. Reducing expression of FOXM1 also decreased the quiescence of human CD34(+) HSCs and progenitor cells, and its downregulation was associated with a subset of myelodysplastic syndrome (MDS). Mechanistically, Foxm1 directly bound to the promoter region of the gene encoding the receptor Nurr1 (Nr4a2; called 'Nurr1' here), inducing transcription, while forced expression of Nurr1 reversed the loss of quiescence observed in Foxm1-deficient cells in vivo. Thus, our studies reveal a previously unrecognized role for Foxm1 as a critical regulator of the quiescence and self-renewal of HSCs mediated at least in part by control of Nurr1 expression.
Titel: |
The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells
|
---|---|
Autor/in / Beteiligte Person: | You Yang Zhao ; Quigley, John G. ; Zhu, Tongyu ; Wen Shu Wu ; Hou, Yu ; Sheng, Yue ; Qian, Zhijian ; Peace, David ; Li, Wen ; Huang, Yong ; Li, Liping ; Zhang, Zhonghui |
Link: | |
Zeitschrift: | Nature Immunology, Jg. 16 (2015-06-29), S. 810-818 |
Veröffentlichung: | Springer Science and Business Media LLC, 2015 |
Medientyp: | unknown |
ISSN: | 1529-2916 (print) ; 1529-2908 (print) |
DOI: | 10.1038/ni.3204 |
Schlagwort: |
|
Sonstiges: |
|