Mineralocorticoids in Essential Hypertension
In: Mineralocorticoids and Hypertension ISBN: 9783540123910; (1983)
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Zugriff:
The pattern of aldosterone excretion during high sodium intake in 100 patients with essential hypertension allowed two groups to be differentiated: In the majority of patients (group A, n = 64), aldosterone excretion was suppressed below 6 µg/day, similar to the level in the normotensive control group. In a second group (group B, n = 36), aldosterone remained above the control range despite forced sodium loading. In group B, serum potassium was significantly lower than in patients of group A (3.81 ± 0.44 mEq/l vs 4.26 ± 0.57 mEq/l, respectively, P < 0.001). The blood-pressure-lowering effect of spironolactone (200 mg/day) was more pronounced among patients in group B. Plasma renin values tended to be lower in group B compared with patients showing suppressed aldosterone. The infusion of angiotensin II (0.1–2 ng/kg body weight/min) led to a more pronounced increase in plasma aldosterone levels in group-B patients compared to group A essential hypertensives, starting from higher plasma-aldosterone baseline values in group B-patients.
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Mineralocorticoids in Essential Hypertension
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Autor/in / Beteiligte Person: | Wambach, G. ; Helber, A. ; Hummerich, W. ; Meurer, K. A. |
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Quelle: | Mineralocorticoids and Hypertension ISBN: 9783540123910; (1983) |
Veröffentlichung: | Springer Berlin Heidelberg, 1983 |
Medientyp: | unknown |
ISBN: | 978-3-540-12391-0 (print) |
DOI: | 10.1007/978-3-642-69081-5_15 |
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