Essential Oil and Leaves from Lantana camara Significantly Ameliorate Different Cancer Cell Lines by Suppressing the NF-κB Pathway
In: Sains Malaysiana, Jg. 50 (2021-10-31), S. 2923-2936
Online
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Zugriff:
The anticancer and anti-inflammatory activities of wild-sage (Lantana camara) leaves essential oil were evaluated against various human cell lines. In this regard, steam hydro-distillation technique was used for oil extraction. Chemical characterization of L. camara essential oil (LCEO) was done by GC-MS, and forty one chemical components (98.69%) were detected in leaves of LCEO. The major constituents were caryophyllene oxide (19.63%), caryophyllene (6.68%), β-phellandrene (6.48%), humulene epoxide II (5.68%), spathulenol (4.17%), α-pinene (3.27%), eucalyptol (3.09%), α-cyclocitral (2.89%), β-pinene (2.38%), and nerolidol II (2.33%). Moreover, the antioxidant and antimicrobial potential of LCEO were also examined. LCEO also showed good anti-inflammatory activity. Interestingly, it was found that the L. camara essential oil was active against a set of microbial strains along with promising antioxidant activity. The MTT assay showed that LCEO possessed good anticancer potential against U-266, A-549, HCT-116, SCC-4, MiaPaCa 2, and KBM-5 cancer cell lines. In these cell lines, it was depicted that the LCEO blocked the tumor cell proliferation via NF-κB pathway suppression. The promising and potent bioactivities of LCEO support the candidature of these essential oils as an anticancer agent.
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Essential Oil and Leaves from Lantana camara Significantly Ameliorate Different Cancer Cell Lines by Suppressing the NF-κB Pathway
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Autor/in / Beteiligte Person: | Imran, Ali ; Tanweer Aslam Gondal ; Manzoor, Qaisar ; Aslam, Farhan ; Hussain, Ghulam ; Rabia Shabir Ahmad ; Arshad, Muhammad ; Sajid, Anam ; Imran, Muhammad ; Sajid, Arfaa |
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Zeitschrift: | Sains Malaysiana, Jg. 50 (2021-10-31), S. 2923-2936 |
Veröffentlichung: | Penerbit Universiti Kebangsaan Malaysia (UKM Press), 2021 |
Medientyp: | unknown |
ISSN: | 2735-0118 (print) ; 0126-6039 (print) |
DOI: | 10.17576/jsm-2021-5010-07 |
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