Antinociceptive, anti-inflammatory activity of the essential oil of Stachys Lavandulifolia Vahl. (Laminaceae) and in (-)-α-Bisabolol, it’s majority component, in rodents
In: Repositório Institucional da UFS Universidade Federal de Sergipe (UFS) instacron:UFS; (2017-07-14)
Online
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Zugriff:
Stachys lavandulifolia Vahl (Lamiaceae) is a medicinal plant widely used in Turkey and in Iranian folk medicine because of its analgesic and anti-inflammatory properties. The objective of this study was to evaluate the antinociceptive and anti-inflammatory effects of the essential oil of S. lavandulifolia (EOSl) and (-)-a-bisabolol (BIS), its main compound, in mice. Chromatographic analysis of EOSl showed the presence of (-)-a-bisabolol (56.4%), bicyclogermacrene (5.3%), d-cadinene (4.2%) and spatulenol (2.9%) as main compounds. Male Swiss mice were pretreated with EOSl (25 or 50 mg/kg, po), BIS (25 or 50 mg/kg, po), morphine (3 mg/kg, ip) or vehicle (saline solution 0.9% with two drops of tween 80). Formalin (20 µl, 2%), capsaicin (20 µl, 2.5 µg) or glutamate (20 µl, 25 µm) were injected into the right upper lip of the mice. The anti-inflammatory profile of EOSl or BIS (50mg/kg) was evaluated by the carrageenan-induced inflammatory response (2% in 0.2mL) (pleurisy model) (CEPA/UFS # 72/2015). Data were expressed as mean ± S.E.M. and the difference between groups was analyzed by ANOVA (one-way) with Tukey post-test (p
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Antinociceptive, anti-inflammatory activity of the essential oil of Stachys Lavandulifolia Vahl. (Laminaceae) and in (-)-α-Bisabolol, it’s majority component, in rodents
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Autor/in / Beteiligte Person: | Amarante, Rosana Silva ; Barreto, Rosana de Souza Siqueira |
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Quelle: | Repositório Institucional da UFS Universidade Federal de Sergipe (UFS) instacron:UFS; (2017-07-14) |
Veröffentlichung: | Pós-Graduação em Ciências Aplicadas à Saúde, 2017 |
Medientyp: | unknown |
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