Essential diurnal Rac1 activation during retinal phagocytosis requires avß5 integrin but not tyrosine kinases focal adhesion kinase or Mer tyrosine kinase
In: Molecular Biology of the Cell, Jg. 23 (2012-03-15), Heft 6, S. 1104-1114
serialPeriodical
Zugriff:
Activation specifically of the GTPase Rac1 in retinal pigment epithelial cells is necessary for F-actin recruitment to and engulfment of photoreceptor debris, a process essential for vision. Rac1 activation requires avß integrin and its ligand milk fat globule-EGF8 but, unexpectedly, is independent of tyrosine kinase signaling via focal adhesion kinase and Mer tyrosine kinase.
Titel: |
Essential diurnal Rac1 activation during retinal phagocytosis requires avß5 integrin but not tyrosine kinases focal adhesion kinase or Mer tyrosine kinase
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Autor/in / Beteiligte Person: | Mao, Yingyu ; Finnemann, Silvia C. |
Zeitschrift: | Molecular Biology of the Cell, Jg. 23 (2012-03-15), Heft 6, S. 1104-1114 |
Veröffentlichung: | 2012 |
Medientyp: | serialPeriodical |
ISSN: | 1059-1524 (print) ; 1939-4586 (print) |
DOI: | 10.1091/mbc.e11-10-0840 |
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