AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila
In: Molecular Biology of the Cell, Jg. 22 (2011-06-15), Heft 12, S. 2094-2105
serialPeriodical
Zugriff:
Clathrin and AP-1 are required for the formation of mucin-type secretory granules in Drosophilalarval salivary gland cells. Clathrin and AP-1 colocalize with secretory cargo at the trans-Golgi network (TGN) and on immature granules. Moreover, clathrin recruitment to the TGN requires AP-1. Strikingly, loss of AP-1 or clathrin profoundly blocks granule biogenesis.
Titel: |
AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila
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Autor/in / Beteiligte Person: | Burgess, Jason ; Jauregui, Miluska ; Tan, Julie ; Rollins, Janet ; Lallet, Sylvie ; Leventis, Peter A. ; Boulianne, Gabrielle L. ; Chang, Henry C. ; Le Borgne, Roland ; Krämer, Helmut ; Brill, Julie A. |
Zeitschrift: | Molecular Biology of the Cell, Jg. 22 (2011-06-15), Heft 12, S. 2094-2105 |
Veröffentlichung: | 2011 |
Medientyp: | serialPeriodical |
ISSN: | 1059-1524 (print) ; 1939-4586 (print) |
DOI: | 10.1091/mbc.e11-01-0054 |
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