The effects and potential mechanisms of essential metals on the associations of polycyclic aromatic hydrocarbons with blood cell-based inflammation markers.
In: Environmental Pollution, Jg. 349 (2024-05-15), S. N.PAG
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Zugriff:
Polycyclic aromatic hydrocarbons (PAHs) are well-acknowledged pro-inflammatory chemicals, but their associations with blood cell-based inflammatory biomarkers need further investigation. Moreover, the effects and mechanisms of essential metals on PAH-related inflammation remain poorly understood. To elucidate the associations of PAHs on inflammatory biomarkers, as well as the effects and mechanisms of essential metals on these associations. A cross-sectional study was conducted on 1388 coke oven workers. We analyzed the modification effects of key essential metal(s) on PAHs-inflammatory biomarkers associations. To explore the possible mechanisms from an inflammation perspective, we performed a bioinformatic analysis on the genes of PAHs and essential metals obtained from the Comparative Toxicogenomics Database (CTD) and performed a mediation analysis. We observed associations of PAHs and essential metals with lymphocyte-to-monocyte ratio (LMR) (P < 0.05). PAH mixtures were inversely associated with LMR (β QGC-index = −0.18, P < 0.001), with 1-hydroxypyrene (1-OH-Pyr) being the most prominent contributor (weight = 63.37 %), whereas a positive association between essential metal mixtures and LMR was observed (β QGC-index = 0.14, P < 0.001), with tin being the most significant contributor (weight = 51.61%). An inverse association of 1-OH-Pyr with LMR was weakened by increased tin exposure (P < 0.05). The CTD database showed that PAHs and tin compounds co-regulated 22 inflammation-associated genes, but they regulated most genes in opposite directions. Further identified the involvement of oxidative stress and mediation analysis showed that the mediation effect of 8-hydroxydeoxyguanosine (8-OHdG) on 1-OH-Pyr-LMR association presented heterogeneity between low and high tin tertile groups (I 2 = 37.84%). 1-OH-Pyr and tin were significantly associated with LMR. Modification effects indicated that the inverse association of 1-OH-Pyr with LMR was mitigated with an increase in tin. The mediation effect of 8-OHdG on the inverse association of 1-OH-Pyr with LMR may be partially dependent on tin. [Display omitted] • PAH mixtures were related to decreased LMR, with pyrene contributing the most. • Essential metals had joint effects on elevated LMR, with tin being predominant. • Tin had a modifying effect on pyrene-LMR association. • Pyrene and tin regulated inflammation-related common genes in opposite directions. • 8-OHdG mediated pyrene-LMR association and partially dependent on the dose of tin. [ABSTRACT FROM AUTHOR]
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Titel: |
The effects and potential mechanisms of essential metals on the associations of polycyclic aromatic hydrocarbons with blood cell-based inflammation markers.
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Autor/in / Beteiligte Person: | Liao, Xiaojing ; Wu, Haimei ; Liu, Kang ; Bai, Yansen ; Wu, Degang ; Guo, Chaofan ; Liu, Xin ; Zhang, Zhaorui ; Huang, Yongshun ; Zhao, Na ; Xiao, Yongmei ; Deng, Qifei |
Zeitschrift: | Environmental Pollution, Jg. 349 (2024-05-15), S. N.PAG |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0269-7491 (print) |
DOI: | 10.1016/j.envpol.2024.123856 |
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