Researchers from Washington University Detail Findings in Carcinomas (Epigenetic and Transcriptomic Characterization Reveals Progression Markers and Essential Pathways In Clear Cell Renal Cell Carcinoma).
In: Genomics & Genetics Weekly, 2024-04-19, S. 1391-1391
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Zugriff:
Researchers from Washington University have conducted a study on clear cell renal cell carcinoma (ccRCC), a type of kidney cancer. Through a multi-omics approach, they identified 20 tumor-specific markers and found an association between higher expression of ceruloplasmin (CP) and reduced survival. The study also revealed insights into the cellular architecture of ccRCC, including the role of CP in regulating tumor-stroma interactions and the presence of tumor cell-intrinsic inflammation and epithelial-mesenchymal transition. Additionally, the researchers found that BAP1 mutations affect chromatin accessibility more significantly than PBRM1 mutations. This study provides valuable information on the markers and pathways involved in ccRCC tumorigenesis. [Extracted from the article]
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Titel: |
Researchers from Washington University Detail Findings in Carcinomas (Epigenetic and Transcriptomic Characterization Reveals Progression Markers and Essential Pathways In Clear Cell Renal Cell Carcinoma).
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Zeitschrift: | Genomics & Genetics Weekly, 2024-04-19, S. 1391-1391 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6467 (print) |
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