Laboratory Corporation of America(R) Holdings Researcher Illuminates Research in Salmonella (Development of a Replication-Deficient Bacteriophage Reporter Lacking an Essential Baseplate Wedge Subunit).

A recent study conducted by researchers at Laboratory Corporation of America(R) Holdings has explored the use of engineered bacteriophages (phages) as diagnostic reporters for detecting bacterial pathogens, specifically Salmonella. The researchers aimed to limit the potential environmental impact of these phages by developing a replication-deficient reporter phage. The study found that the engineered phage, SEA1Dgp141.NL, demonstrated accurate and sensitive detection of Salmonella despite its inability to replicate. This research suggests that replication-deficient reporter phages can provide improved containment without sacrificing performance or ease of production. [Extracted from the article]

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