Chemical composition and biological activity of essential oil of Teucrium scordium L. subsp. scordioides (Schreb.) Arcang. (Lamiaceae) from Sardinia Island (Italy).
In: Natural Product Research, Jg. 36 (2022-11-15), Heft 22, S. 5828-5835
academicJournal
Zugriff:
The aim of this study is to demonstrate the antifungal, anti-inflammatory and anti-migratory potential of the essential oil of Teucrium scordium subsp. scordioides (Schreb.) Arcang, a plant widely used in traditional medicine in Sardinia. The oil was rich in germacrene D (25.1%), δ-cadinene (12.9%) and alloaromadendrene (11.3%). The yeast Cryptococcus neoformans and the dermatophytes Trichophyton rubrum, T. mentagrophytes var. interdigitale and Epidermophyton floccosum were the most susceptible fungi to the action of the oil. In lipopolysaccharide (LPS)-stimulated macrophages, the oil was able to decrease nitric oxide production by ca. 30% at 1.25 μL/mL, without affecting cell viability. In the scratch wound assay, it allowed for ca. 36% of wound closure after 18 h, thus showing anti-migratory properties. Overall, this study highlights the potential of this species to mitigate fungal infections associated with an inflammatory response. Furthermore, we also reported for the first time its anti-migratory capacity, thus suggesting anticancer properties. [ABSTRACT FROM AUTHOR]
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Titel: |
Chemical composition and biological activity of essential oil of Teucrium scordium L. subsp. scordioides (Schreb.) Arcang. (Lamiaceae) from Sardinia Island (Italy).
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Autor/in / Beteiligte Person: | Piras, Alessandra ; Maccioni, Alfredo ; Falconieri, Danilo ; Porcedda, Silvia ; Gonçalves, Maria José ; Alves-Silva, Jorge M. ; Silva, Ana ; Cruz, Maria Teresa ; Salgueiro, Ligia ; Maxia, Andrea |
Zeitschrift: | Natural Product Research, Jg. 36 (2022-11-15), Heft 22, S. 5828-5835 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1478-6419 (print) |
DOI: | 10.1080/14786419.2021.2018432 |
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