7-Hydroxycoumarin Induces Vasorelaxation in Animals with Essential Hypertension: Focus on Potassium Channels and Intracellular Ca 2+ Mobilization.
In: Molecules, Jg. 27 (2022-11-01), Heft 21, S. 7324-7340
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Zugriff:
Cardiovascular diseases (CVD) are the deadliest noncommunicable disease worldwide. Hypertension is the most prevalent risk factor for the development of CVD. Although there is a wide range of antihypertensive drugs, there still remains a lack of blood pressure control options for hypertensive patients. Additionally, natural products remain crucial to the design of new drugs. The natural product 7-hydroxycoumarin (7-HC) exhibits pharmacological properties linked to antihypertensive mechanisms of action. This study aimed to evaluate the vascular effects of 7-HC in an experimental model of essential hypertension. The isometric tension measurements assessed the relaxant effect induced by 7-HC (0.001 μM–300 μM) in superior mesenteric arteries isolated from hypertensive rats (SHR, 200–300 g). Our results suggest that the relaxant effect induced by 7-HC rely on K + -channels (K ATP , BK Ca , and, to a lesser extent, K v ) activation and also on Ca 2+ influx from sarcolemma and sarcoplasmic reticulum mobilization (inositol 1,4,5-triphosphate (IP3) and ryanodine receptors). Moreover, 7-HC diminishes the mesenteric artery's responsiveness to α1-adrenergic agonist challenge and improves the actions of the muscarinic agonist and NO donor. The present work demonstrated that the relaxant mechanism of 7-HC in SHR involves endothelium-independent vasorelaxant factors. Additionally, 7-HC reduced vasoconstriction of the sympathetic agonist while improving vascular endothelium-dependent and independent relaxation. [ABSTRACT FROM AUTHOR]
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Titel: |
7-Hydroxycoumarin Induces Vasorelaxation in Animals with Essential Hypertension: Focus on Potassium Channels and Intracellular Ca 2+ Mobilization.
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Autor/in / Beteiligte Person: | Jesus, Rafael L. C. ; Silva, Isnar L. P. ; Araújo, Fênix A. ; Moraes, Raiana A. ; Silva, Liliane B. ; Brito, Daniele S. ; Lima, Gabriela B. C. ; Alves, Quiara L. ; Silva, Darizy F. |
Zeitschrift: | Molecules, Jg. 27 (2022-11-01), Heft 21, S. 7324-7340 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1420-3049 (print) |
DOI: | 10.3390/molecules27217324 |
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