Cytochrome P450 Monooxygenases Catalyse Steroid Nucleus Hydroxylation with Regio‐ and Stereo‐Selectivity.
In: Advanced Synthesis & Catalysis, Jg. 364 (2022-08-16), Heft 16, S. 2701-2719
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Zugriff:
Steroids are the second largest class of drugs with a wide range of pharmacological properties. Hydroxylation of steroids seriously affects their biological activities and other properties. However, steroids are mostly sp3 hybridized carbons with numerous C−H bonds far from the functional group that can activate them, and achieving regio‐ and stereo‐selective hydroxylation on steroids is a highly challenging task that is almost impossible to achieve using modern organic synthesis techniques. Interestingly, cytochrome P450 monooxygenases possess the ability to catalyse regio‐ and stereo‐selective oxidations of nonactivated C−H bonds in complex organic molecules under mild conditions. This review summarizes the P450s identified and engineered in recent years that can catalyse steroid nucleus hydroxylation stereo‐ and regio‐selectively. [ABSTRACT FROM AUTHOR]
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Cytochrome P450 Monooxygenases Catalyse Steroid Nucleus Hydroxylation with Regio‐ and Stereo‐Selectivity.
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Autor/in / Beteiligte Person: | Zhu, Rui ; Liu, Yang ; Yang, Yueying ; Min, Qing ; Li, Hua ; Chen, Lixia |
Zeitschrift: | Advanced Synthesis & Catalysis, Jg. 364 (2022-08-16), Heft 16, S. 2701-2719 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1615-4150 (print) |
DOI: | 10.1002/adsc.202200210 |
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