A PHARMACOVIGILANCE ANALYSIS OF ANTIHYPERTENSIVE DRUGS IN ESSENTIAL HYPERTENSION PATIENTS IN TERTIARY CARE HOSPITAL.
In: Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), Jg. 13 (2022-10-01), Heft 4, S. 12-20
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Zugriff:
INTRODUCTION Hypertension is the most common cardiovascular disease and most important public health problem. Elevated arterial pressure causes hypertrophy of the left ventricle and pathological changes in the vasculature. Pharmacovigilance analysis study provided an insight into the drug use pattern and rational use of a drugs (prescribe well documented drug at an optimal dose, together with the correct information, at an affordable price). The outcomes of this contribute to our knowledge about drugs effectiveness and safety. MATERIALS AND METHODS: A pharmacovigilance analysis study was an observation, prospective. The pharmacovigilance analysis of ADRs of antihypertensive drugs observed study was conducted at tertiary care hospital in medical sciences teaching hospital. After pharmacovigilance analysis design and planning data collection was done for 4 months of period. After observation study and data collection analysis was done. Total duration of the pharmacovigilance ADRs Data analysis study was 2 years of duration. RESULT Total of 380 prescriptions were collected as per inclusion and exclusion criterion and ADRs were also collected and 89 ADRs were collected and analysed. In my research study, it was detected that CCBs were the most common used anti-hypertensive drugs incidence to ADRs i. e., 31 (34.83%) and other anti-hypertensive drugs with incidence to ADRs were ACEIs (n=24, 26.96%), ARBs (n=16, 17.98%), ß-blockers (n=5, 5.62%) and diuretics (n=13, 14.61%). In my research study, it was found that CNS (n=39, 43.82%) were the most common. Other affected system was CVS (n=21, 23.60%), Musculo-skeletal system (n=11, 12.36%), GI system (n=9, 10.11%), respiratory system (n=5, 5.61%) and skin (n=4, 4.50%). CONCLUSION In pharmacovigilance research study, calcium channel blocker (CCBs) was noted the most frequently associated drugs both as monotherapy and in combined therapy have been used, in present study were found most ADRs followed by ACEI, ARB and Diuretics. [ABSTRACT FROM AUTHOR]
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Titel: |
A PHARMACOVIGILANCE ANALYSIS OF ANTIHYPERTENSIVE DRUGS IN ESSENTIAL HYPERTENSION PATIENTS IN TERTIARY CARE HOSPITAL.
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Autor/in / Beteiligte Person: | Chouhan, Ashok Singh ; Puranik, Sangamesh B. ; Mishra, Rabindranath |
Zeitschrift: | Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), Jg. 13 (2022-10-01), Heft 4, S. 12-20 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 0975-3583 (print) |
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