WHO essential medicines for children 2011-2019: age-appropriateness of enteral formulations.
In: Archives of Disease in Childhood, Jg. 107 (2022-04-01), Heft 4, S. 317-322
academicJournal
Zugriff:
Introduction: The WHO Essential Medicine List for children (EMLc) is used for promoting access to medicines. The age-appropriateness of enteral (oral and rectal) formulations for children depend on their adaptability/flexibility to allow age-related or weight-related doses to be administered/prescribed and the child's ability to swallow, as appropriate. There is scant information on the age-appropriateness of essential enteral medicines for children. Objective: To evaluate the age-appropriateness of enteral essential medicines. Materials and Methods: Age-appropriateness of all enteral formulations indicated and recommended in the EMLc 3rd to 7th (2011-2019) editions were determined by assessing swallowability and/or dose adaptability for children under 12 years, stratified into five age groups. Results: Enteral formulations in the EMLc were more age-appropriate for older children aged 6-11 years than for younger children. In the 3rd edition, for older children, 77%, n=342, of formulations were age-appropriate. For younger children, age-appropriateness decreased with age group: 34% in those aged 3-5 years, 30% in those aged 1-2 years, 22% among those aged 28 days to 11 months and 15% in those aged 0-27 days. Overall, similar proportions were found for the 7th edition. In contrast, the majority of medicines in the 7th list were age-appropriate in targeted diseases like HIV and tuberculosis. Conclusion: Most recommended enteral essential medicines in EMLc 2011 and 2019 were not age-appropriate for children <6 years. Medicines which are not age-appropriate must be manipulated before administration, leading to potential issues of safety and efficacy. Evaluation of the age-appropriateness of formulations for medicines to be included in EMLc could improve access to better medicines for children in the future. [ABSTRACT FROM AUTHOR]
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WHO essential medicines for children 2011-2019: age-appropriateness of enteral formulations.
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Autor/in / Beteiligte Person: | Orubu, Ebiowei Samuel F. ; Duncan, Jennifer ; Tuleu, Catherine ; Turner, Mark A. ; Nunn, Anthony |
Zeitschrift: | Archives of Disease in Childhood, Jg. 107 (2022-04-01), Heft 4, S. 317-322 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 0003-9888 (print) |
DOI: | 10.1136/archdischild-2021-321831 |
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