Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China.
In: Journal of the Renin-Angiotensin-Aldosterone System, Jg. 21 (2020-10-01), Heft 4, S. 1-7
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Zugriff:
Objective: Prolylcarboxypeptidase (PRCP) is both involved in the Kallikrein-Kinin system (KKS) and renin-angiotensin-aldosterone system (RAAS). This study aimed to determine the genetic impact of PRCP gene polymorphisms on essential hypertension (EH) in an isolated population from a remote region of China. Methods: A haplotype-based study was investigated in 346 EH patients and 346 normal subjects and all samples were Hani minority residents in Southwest China. A total of 11 tag single nucleotide polymorphisms (SNPs) in PRCP gene were tested by polymerase chain reaction-restriction fragment length polymorphism method. Results: Single site analysis found that PRCP gene 3'UTR SNP rs3750931 was associated with EH. The minor allele G of rs3750931 was more prevalent in the EH patients compared to control subjects after Bonferroni correction (p < 0.05). Moreover, the rs3750931 G allele carriers showed higher average blood pressure (BP) level among the subjects. The H2 (GAGCACTAACA) haplotype without rs3750931 G allele showed the protective effect for EH (OR = 0.68, 95 CI 0.54-0.85, p = 0.001). Conclusion: The present study indicated PRCP gene rs3750931 was associated with the risk of EH. This SNP G allele could be considered as one of risk markers for EH in Hani population. [ABSTRACT FROM AUTHOR]
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Titel: |
Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China.
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Autor/in / Beteiligte Person: | Wu, Yanrui ; Pan, Xingming ; Jin, Xiaoxiao |
Zeitschrift: | Journal of the Renin-Angiotensin-Aldosterone System, Jg. 21 (2020-10-01), Heft 4, S. 1-7 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 1470-3203 (print) |
DOI: | 10.1177/1470320320981316 |
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