Menthol-Induced Cutaneous Vasodilation Is Preserved in Essential Hypertensive Men and Women.
In: American Journal of Hypertension, Jg. 30 (2017-12-01), Heft 12, S. 1156-1162
academicJournal
Zugriff:
BACKGROUND Menthol is a selective transient receptor potential melastatin 8 (TRPM8) channel agonist that induces cutaneous vasodilation in young, normotensive men and women through nitric oxide synthase (NOS)-, endothelium-derived hyperpolarizing factor (EDHF)-, and sensory nerve-mediated mechanisms. Microvascular dysfunction is present in essential hypertension and whether menthol induces vasodilation is men and women with essential hypertension is equivocal. METHODS Four intradermal microdialysis fibers were placed in the forearm of 9 essential hypertensive and 10 age-matched normotensive control subjects. Sites were pretreated with lactated Ringer's (control), L-NAME (NOS inhibited), TEA (EDHF inhibited), and lidocaine (sensory nerve inhibited). The microdialysis fibers were then perfused with 7 increasing doses of menthol (0.1-500 mM). Red cell flux in response to menthol was measured with laser Doppler flowmetry. Data were normalized to mean arterial pressure and presented as a percentage of site-specific maximum vasodilation (%CVC max ). RESULTS At the control site, menthol caused vasodilation in both the normotensive and hypertensive groups (menthol doses 100, 250, and 500 mM; all P < 0.05 compared to baseline). There were no differences between groups (P = 0.58, main effect). There was no effect of either NOS or sensory nerve inhibition on menthol-induced vasodilation in the normotensive group; however, menthol-induced vasodilation was attenuated with NOS and sensory nerve inhibition in the hypertensive group. EDHF inhibition attenuated menthol-induced vasodilation in both groups. CONCLUSIONS Menthol-induced vasodilation has NO, EDHF, and sensory nerve components. Menthol-induced cutaneous vasodilation is preserved in hypertensive subjects. However, the hypertensive subjects exhibited a loss of redundant vasodilator systems. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Hypertension is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Menthol-Induced Cutaneous Vasodilation Is Preserved in Essential Hypertensive Men and Women.
|
---|---|
Autor/in / Beteiligte Person: | Craighead, Daniel H. ; Alexander, Lacy M. |
Zeitschrift: | American Journal of Hypertension, Jg. 30 (2017-12-01), Heft 12, S. 1156-1162 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 0895-7061 (print) |
DOI: | 10.1093/ajh/hpx127 |
Schlagwort: |
|
Sonstiges: |
|