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Transdermal drug delivery offers a promising alternative for administering medications like ibuprofen, known for its analgesic and anti-inflammatory properties, with reduced gastrointestinal side effects compared to oral administration. This study explored the potential synergistic effects of combining ibuprofen with lavender essential oil (LEO) in transdermal patches. The composition of LEO was analyzed, revealing predominant compounds such as linalyl acetate and linalool, which are known for their analgesic and anti-inflammatory properties. The physicochemical properties of the patches were investigated, indicating improved cohesion with the addition of LEO. Additionally, thermal stability assessments demonstrated enhanced stability with LEO incorporation with an increase in onset decomposition temperature from 49.0 to 67.9 °C. The antioxidant activity of patches containing LEO was significantly higher with a free radical scavenging ability of 79.13% RSA compared to 60% RSA in patches without LEO. Release and permeation studies showed that patches with LEO exhibited an increased permeation of ibuprofen through the skin with 74.40% of the drug released from LEO-containing patches compared to 36.29% from patches without LEO after 24 h. Moreover, the permeation rate was notably faster with LEO, indicating quicker therapeutic effects. The inclusion of LEO in transdermal patches containing ibuprofen holds promise for enhancing drug delivery efficiency and therapeutic effectiveness, offering a potential strategy for improved pain management with reduced side effects.

Titel:	Medicinal Anti-Inflammatory Patch Loaded with Lavender Essential Oil.
Autor/in / Beteiligte Person:	Zyburtowicz, K ; Bednarczyk, P ; Nowak, A ; Muzykiewicz-Szymańska, A ; Kucharski, Ł ; Wesołowska, A ; Ossowicz-Rupniewska, P
Zeitschrift:	International journal of molecular sciences, Jg. 25 (2024-06-04), Heft 11
Veröffentlichung:	Basel, Switzerland : MDPI, [2000-, 2024
Medientyp:	academicJournal
ISSN:	1422-0067 (electronic)
DOI:	10.3390/ijms25116171
Schlagwort:	Administration, Cutaneous Animals Antioxidants chemistry Antioxidants pharmacology Antioxidants administration & dosage Drug Liberation Acyclic Monoterpenes Monoterpenes Oils, Volatile chemistry Oils, Volatile pharmacology Oils, Volatile administration & dosage Lavandula chemistry Plant Oils chemistry Plant Oils pharmacology Ibuprofen chemistry Ibuprofen administration & dosage Ibuprofen pharmacology Transdermal Patch Anti-Inflammatory Agents pharmacology Anti-Inflammatory Agents chemistry Anti-Inflammatory Agents administration & dosage
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int J Mol Sci] 2024 Jun 04; Vol. 25 (11). <i>Date of Electronic Publication: </i>2024 Jun 04. MeSH Terms: Oils, Volatile* / chemistry ; Oils, Volatile* / pharmacology ; Oils, Volatile* / administration & dosage ; Lavandula* / chemistry ; Plant Oils* / chemistry ; Plant Oils* / pharmacology ; Ibuprofen* / chemistry ; Ibuprofen* / administration & dosage ; Ibuprofen* / pharmacology ; Transdermal Patch* ; Anti-Inflammatory Agents* / pharmacology ; Anti-Inflammatory Agents* / chemistry ; Anti-Inflammatory Agents* / administration & dosage ; Administration, Cutaneous ; Animals ; Antioxidants / chemistry ; Antioxidants / pharmacology ; Antioxidants / administration & dosage ; Drug Liberation ; Acyclic Monoterpenes ; Monoterpenes References: Evid Based Complement Alternat Med. 2018 Mar 18;2018:1413940. (PMID: 29743918) ; PLoS One. 2017 May 3;12(5):e0176699. (PMID: 28467450) ; Nat Prod Commun. 2014 Jun;9(6):859-62. (PMID: 25115100) ; Nat Prod Res. 2012 Nov;26(21):1976-84. (PMID: 22117129) ; J Control Release. 2002 May 17;81(1-2):121-33. (PMID: 11992685) ; Asian Pac J Trop Biomed. 2014 May;4(Suppl 1):S298-304. (PMID: 25183101) ; J Zhejiang Univ Sci B. 2014 Feb;15(2):153-64. (PMID: 24510708) ; Drug Deliv Transl Res. 2022 Apr;12(4):758-791. (PMID: 33474709) ; Oxid Med Cell Longev. 2016;2016:3403586. (PMID: 27630758) ; Zhongguo Zhong Yao Za Zhi. 2018 Sep;43(17):3493-3497. (PMID: 30347917) ; Phytomedicine. 2002 Dec;9(8):721-6. (PMID: 12587692) ; Pharmaceutics. 2023 Feb 01;15(2):. (PMID: 36839811) ; Gels. 2023 May 08;9(5):. (PMID: 37232983) ; Molecules. 2021 Sep 18;26(18):. (PMID: 34577152) ; Planta Med. 2016 Jan;82(1-2):163-70. (PMID: 26441063) ; Drug Dev Ind Pharm. 2007 Dec;33(12):1369-74. (PMID: 18097811) ; Adv Healthc Mater. 2024 Mar;13(7):e2302375. (PMID: 38009520) ; Pak J Pharm Sci. 2018 Jul;31(4(Supplementary)):1603-1608. (PMID: 30058555) ; ISRN Pharmacol. 2012;2012:435214. (PMID: 22530141) ; Int J Clin Pediatr Dent. 2022 May-Jun;15(3):385-388. (PMID: 35991803) ; Pharmaceutics. 2021 Mar 03;13(3):. (PMID: 33802570) ; J Chemother. 2019 Feb;31(1):9-14. (PMID: 30508410) ; BMC Infect Dis. 2010 Sep 22;10:278. (PMID: 20860796) ; Int J Mol Sci. 2021 Jun 10;22(12):. (PMID: 34200719) ; Int J Pharm. 2001 Aug 14;224(1-2):81-8. (PMID: 11472817) ; Int Immunopharmacol. 2019 Sep;74:105706. (PMID: 31254955) ; J Lipid Res. 2020 Jun;61(6):884-895. (PMID: 32265320) ; Pharm Biol. 2016;54(6):1042-51. (PMID: 26510896) ; Front Pharmacol. 2017 May 19;8:280. (PMID: 28579958) ; AAPS J. 2008;10(1):120-32. (PMID: 18446512) ; Colloids Surf B Biointerfaces. 2008 Sep 1;65(2):300-7. (PMID: 18579348) ; J Pharm Pharmacol. 2015 Apr;67(4):473-85. (PMID: 25557808) ; Heliyon. 2023 Apr 14;9(5):e15446. (PMID: 37153408) ; Molecules. 2015 Oct 07;20(10):18219-36. (PMID: 26457698) ; J Control Release. 2022 Nov;351:361-380. (PMID: 36169040) ; Angew Chem Int Ed Engl. 2023 Mar 1;62(10):e202214795. (PMID: 36478123) ; Medicina (Kaunas). 2023 Apr 17;59(4):. (PMID: 37109736) ; Molecules. 2021 Jun 07;26(11):. (PMID: 34200200) ; Plants (Basel). 2022 Jan 25;11(3):. (PMID: 35161292) ; Pharm Biol. 2017 Dec;55(1):1592-1600. (PMID: 28399694) ; Drug Deliv. 2021 Dec;28(1):1043-1054. (PMID: 34060397) ; Inflammopharmacology. 2009 Dec;17(6):275-342. (PMID: 19949916) ; J Ethnopharmacol. 2003 Nov;89(1):67-71. (PMID: 14522434) ; Int J Mol Sci. 2023 Oct 26;24(21):. (PMID: 37958615) ; Mol Pharm. 2023 Jul 3;20(7):3278-3297. (PMID: 37279070) ; Int J Cosmet Sci. 2012 Aug;34(4):347-56. (PMID: 22515469) ; Pharmaceutics. 2023 Oct 03;15(10):. (PMID: 37896173) ; AAPS PharmSciTech. 2020 Jan 27;21(3):84. (PMID: 31989358) Contributed Indexing: Keywords: Lavandula angustifolia; adhesion; cohesion; ibuprofen; lavender essential oil; transdermal patch Substance Nomenclature: 0 (Oils, Volatile) ; ZBP1YXW0H8 (lavender oil) ; 0 (Plant Oils) ; WK2XYI10QM (Ibuprofen) ; 0 (Anti-Inflammatory Agents) ; 0 (Antioxidants) ; 5K47SSQ51G (linalyl acetate) ; D81QY6I88E (linalool) ; 0 (Acyclic Monoterpenes) ; 0 (Monoterpenes) Entry Date(s): Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240620 Update Code: 20240620 PubMed Central ID: PMC11173169

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Medicinal Anti-Inflammatory Patch Loaded with Lavender Essential Oil.