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Background: The chemical composition and biological activities of Eucalyptus essential oils (EOs) have been documented in numerous studies against multiple infectious diseases. The antibacterial activity of individual Eucalyptus EOs against strains that cause ear infections was investigated in our previous study. The study's antibacterial activity was promising, which prompted us to explore this activity further with EO blends.

Methods: We tested 15 combinations (9 binary combinations and 6 combinations of binary combinations) of Eucalyptus EOs extracted by hydrodistillation from eight Tunisian Eucalyptus species dried leaves against six bacterial strains responsible for ear infections: three bacterial isolates (Haemophilus influenzae, Haemophilus parainfluenzae, and Klebsiella pneumoniae) and three reference bacteria strains (Pseudomonas aeruginosa, ATTC 9027; Staphylococcus aureus, ATCC 6538; and Escherichia coli, ATCC 8739). The EOs were analyzed using GC/FID and GC/MS. The major compounds, as well as all values obtained from the bacterial growth inhibition assay, were utilized for statistical analysis.

Results: The antibacterial activity of the EO blends exhibited significant variation within Eucalyptus species, bacterial strains, and the applied methods. Principal component analysis (PCA) and hierarchical cluster analysis (HCA), based on the diameters of the inhibition zone, facilitated the identification of two major groups and ten subgroups based on the level of antibacterial activity. The highest antibacterial activity was observed for the mixture of EOs extracted from E. panctata, E. accedens, and E. cladoclayx (paac) as well as E. panctata, E. wandoo, E. accedens, and E. cladoclayx (pwac) using the disc diffusion method. Additionally, significant activity was noted with EOs extracted from E. panctata, E. wandoo (pw) and E. panctata, E. accedens (pa) using the broth microdilution method.

Conclusion: Our findings suggest that certain EO combinations (paac, pwac, pw, and pa) could be considered as potential alternative treatment for ear infections due to their demonstrated highly promising antibacterial activities.

Titel:	Chemical compositions of Eucalyptus sp. Essential oils and the evaluation of their combinations as a promising treatment against ear bacterial infections.
Autor/in / Beteiligte Person:	Ameur, E ; Sarra, M ; Yosra, D ; Mariem, K ; Nabil, A ; Ibrahim, J ; Alarjani, KM ; Lynen, F ; Larbi, KM
Zeitschrift:	BMC complementary medicine and therapies, Jg. 24 (2024-06-07), Heft 1, S. 220
Veröffentlichung:	London : BioMed Central, [2020]-, 2024
Medientyp:	academicJournal
ISSN:	2662-7671 (electronic)
DOI:	10.1186/s12906-024-04494-2
Schlagwort:	Humans Bacterial Infections drug therapy Bacteria drug effects Plant Oils pharmacology Plant Oils chemistry Eucalyptus chemistry Oils, Volatile pharmacology Oils, Volatile chemistry Anti-Bacterial Agents pharmacology Anti-Bacterial Agents chemistry Microbial Sensitivity Tests
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [BMC Complement Med Ther] 2024 Jun 07; Vol. 24 (1), pp. 220. <i>Date of Electronic Publication: </i>2024 Jun 07. MeSH Terms: Eucalyptus* / chemistry ; Oils, Volatile* / pharmacology ; Oils, Volatile* / chemistry ; Anti-Bacterial Agents* / pharmacology ; Anti-Bacterial Agents* / chemistry ; Microbial Sensitivity Tests* ; Humans ; Bacterial Infections / drug therapy ; Bacteria / drug effects ; Plant Oils / pharmacology ; Plant Oils / chemistry References: Front Microbiol. 2017 Jan 16;7:2161. (PMID: 28138324) ; Springerplus. 2016 Apr 16;5:466. (PMID: 27119070) ; Inflammopharmacology. 2017 Apr;25(2):223-235. (PMID: 28239782) ; Toxicol Mech Methods. 2007;17(8):441-50. (PMID: 20020870) ; Animals (Basel). 2020 Jan 20;10(1):. (PMID: 31968596) ; Arch Microbiol. 2020 Jul;202(5):1231-1240. (PMID: 32108246) ; BMC Complement Med Ther. 2021 Aug 12;21(1):209. (PMID: 34384412) ; J Microbiol Immunol Infect. 2014 Jun;47(3):211-6. (PMID: 23274083) ; J Antimicrob Chemother. 2009 Dec;64(6):1219-25. (PMID: 19837714) ; Pharm Biol. 2011 Sep;49(9):893-9. (PMID: 21591991) ; Microb Pathog. 2020 Apr;141:104008. (PMID: 31991163) ; Foodborne Pathog Dis. 2012 Aug;9(8):699-705. (PMID: 22827568) ; Int J Microbiol. 2016;2016:8724671. (PMID: 26904125) ; Int J Food Microbiol. 1997 Jul 22;37(2-3):155-62. (PMID: 9310850) ; Pharmaceuticals (Basel). 2013 Nov 25;6(12):1451-74. (PMID: 24287491) ; Eur J Pharm Biopharm. 2018 May;126:211-220. (PMID: 28583590) ; Evid Based Complement Alternat Med. 2021 Aug 28;2021:1305264. (PMID: 34497653) ; Molecules. 2012 Apr 02;17(4):3989-4006. (PMID: 22469594) ; Open Microbiol J. 2014 Feb 07;8:6-14. (PMID: 24627729) ; Front Microbiol. 2012 Jan 25;3:12. (PMID: 22291693) ; Phytomedicine. 2010 Nov;17(13):1061-6. (PMID: 20727725) ; Folia Microbiol (Praha). 2001;46(2):113-7. (PMID: 11501396) ; Braz J Microbiol. 2015 Mar 04;45(4):1409-13. (PMID: 25763048) ; Int J Pharm. 2001 Mar 14;215(1-2):229-40. (PMID: 11250108) ; Folia Microbiol (Praha). 2021 Feb;66(1):59-67. (PMID: 32895862) ; J Appl Microbiol. 2001 Sep;91(3):492-7. (PMID: 11556915) ; J Food Drug Anal. 2017 Apr;25(2):403-408. (PMID: 28911683) ; Molecules. 2014 Nov 03;19(11):17773-98. (PMID: 25372394) ; Food Chem Toxicol. 2008 Feb;46(2):446-75. (PMID: 17996351) ; Molecules. 2022 Nov 02;27(21):. (PMID: 36364298) Contributed Indexing: Keywords: Eucalyptus essential oils; EOs blends, Antibacterial activity; Ear infection, Principal Component Analysis (PCA); Hierarchical Cluster Analysis (HCA) Substance Nomenclature: 0 (Oils, Volatile) ; 0 (Anti-Bacterial Agents) ; 0 (Plant Oils) Entry Date(s): Date Created: 20240607 Date Completed: 20240607 Latest Revision: 20240611 Update Code: 20240611 PubMed Central ID: PMC11157906

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Chemical compositions of Eucalyptus sp. Essential oils and the evaluation of their combinations as a promising treatment against ear bacterial infections.