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Both Parkinson disease (PD) and Essential tremor (ET) are movement disorders causing tremors in elderly individuals. Although PD and ET are different disease, they often present with similar initial symptoms, making their differentiation challenging with magnetic resonance imaging (MRI) techniques. This study aimed to identify structural brain differences among PD, ET, and health controls (HCs) using 7-Tesla (T) MRI. We assessed the whole-brain parcellation in gray matter volume, thickness, subcortical volume, and small regions of basal ganglia in PD (n = 18), ET (n = 15), and HCs (n = 18), who were matched for age and sex. Brain structure analysis was performed automatic segmentation through Freesurfer software. Small regions of basal ganglia were manually segmented by ITK-SNAP. Additionally, we examined the associations between clinical indicators (symptom duration, unified Parkinson diseases rating scale (UPDRS), and clinical rating scale for tremor (CRST)) and brain structure. PD showed a significant reduction in gray matter volume in the postcentral region compared to ET. ET showed a significant reduction in cerebellum volume compared to HCs. There was a negative correlation between CRST scores (B and C) and gray matter thickness in right superior frontal in ET. This study demonstrated potential of 7T MRI in differentiating brain structure differences among PD, ET, and HCs. Specific findings, such as parietal lobe atrophy in PD compared to ET and cerebellum atrophy in ET compared to HCs, the importance of advanced imaging techniques in accurately diagnosing and distinguishing between movement disorders that present with similar initial symptoms.

Competing Interests: The authors have no funding and conflicts of interest to disclose.

Titel:	Brain structure comparison among Parkinson disease, essential tremor, and healthy controls using 7T MRI.
Autor/in / Beteiligte Person:	Moon, HC ; Kim, A ; Park, YS
Zeitschrift:	Medicine, Jg. 103 (2024-05-10), Heft 19, S. e38139
Veröffentlichung:	Hagerstown, Md : Lippincott Williams & Wilkins, 2024
Medientyp:	academicJournal
ISSN:	1536-5964 (electronic)
DOI:	10.1097/MD.0000000000038139
Schlagwort:	Humans Female Male Aged Middle Aged Case-Control Studies Gray Matter diagnostic imaging Gray Matter pathology Essential Tremor diagnostic imaging Essential Tremor pathology Parkinson Disease diagnostic imaging Parkinson Disease pathology Magnetic Resonance Imaging methods Brain diagnostic imaging Brain pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Comparative Study Language: English [Medicine (Baltimore)] 2024 May 10; Vol. 103 (19), pp. e38139. MeSH Terms: Essential Tremor* / diagnostic imaging ; Essential Tremor* / pathology ; Parkinson Disease* / diagnostic imaging ; Parkinson Disease* / pathology ; Magnetic Resonance Imaging* / methods ; Brain* / diagnostic imaging ; Brain* / pathology ; Humans ; Female ; Male ; Aged ; Middle Aged ; Case-Control Studies ; Gray Matter / diagnostic imaging ; Gray Matter / pathology References: AJNR Am J Neuroradiol. 2009 Jun;30(6):1240-3. (PMID: 19342539) ; Brain Topogr. 2014 Mar;27(2):209-12. (PMID: 23749257) ; J Neurol Sci. 2005 Jun 15;233(1-2):55-9. (PMID: 15893328) ; Neurology. 2006 Oct 24;67(8):1452-6. (PMID: 17060572) ; Int J Clin Exp Med. 2015 Sep 15;8(9):15383-92. (PMID: 26629027) ; AJNR Am J Neuroradiol. 2009 Apr;30(4):699-702. (PMID: 19147714) ; Neurology. 2009 May 26;72(21 Suppl 4):S1-136. (PMID: 19470958) ; Nat Genet. 1997 Sep;17(1):84-7. (PMID: 9288103) ; Mov Disord. 2004 Sep;19(9):1020-8. (PMID: 15372591) ; Acta Neurol Scand. 2009 Jan;119(1):17-21. (PMID: 18549415) ; Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S176-8. (PMID: 26411503) ; Ann Neurol. 2001 Sep;50(3):389-400. (PMID: 11558796) ; MAGMA. 2008 Mar;21(1-2):63-72. (PMID: 18064501) ; Ann Nucl Med. 2012 May;26(4):337-44. (PMID: 22382608) ; Acta Neuropathol. 2013 Jun;125(6):879-89. (PMID: 23543187) ; Am J Med Genet A. 2008 Feb 15;146A(4):433-9. (PMID: 18203159) ; Mov Disord Clin Pract. 2017 Nov 23;5(1):60-65. (PMID: 30363460) ; Curr Opin Neurol. 2010 Aug;23(4):388-93. (PMID: 20489616) ; IEEE Trans Med Imaging. 2007 Mar;26(3):405-21. (PMID: 17354645) ; Radiology. 1987 Jun;163(3):793-9. (PMID: 3575734) ; IEEE Trans Med Imaging. 1998 Feb;17(1):87-97. (PMID: 9617910) ; Neuroimage Clin. 2014 May 09;5:217-31. (PMID: 25068111) ; Lancet Neurol. 2004 Dec;3(12):719-28. (PMID: 15556804) ; PLoS One. 2014 Dec 02;9(12):e114167. (PMID: 25463618) ; J Neuropathol Exp Neurol. 1996 Mar;55(3):259-72. (PMID: 8786384) ; Neuroimage. 2009 Jun;46(2):432-46. (PMID: 19233292) ; Cerebellum. 2016 Apr;15(2):174-81. (PMID: 26062905) ; MAGMA. 2016 Jun;29(3):535-41. (PMID: 27072685) ; Int J Neurosci. 2014 Mar;124(3):175-80. (PMID: 23879402) ; Clin Neuroradiol. 2013 Mar;23(1):17-23. (PMID: 23015059) ; Neurology. 2003 Jun 24;60(12):1985-7. (PMID: 12821747) ; J Neuroimaging. 2012 Jul;22(3):275-8. (PMID: 21447032) ; Tremor Other Hyperkinet Mov (N Y). 2012;2:. (PMID: 23439882) ; AJNR Am J Neuroradiol. 2015 Jul;36(7):1204-15. (PMID: 25523591) ; J Neurosci. 2015 Jan 14;35(2):795-806. (PMID: 25589772) ; Eur Radiol. 2016 Jan;26(1):271-7. (PMID: 25991481) ; Magn Reson Med. 2006 Jul;56(1):216-23. (PMID: 16767762) ; Nucl Med Commun. 2008 Apr;29(4):349-53. (PMID: 18317299) ; Neuroimage. 2013 Apr 15;70:122-31. (PMID: 23261638) ; Ann Neurol. 2008 Sep;64(3):255-65. (PMID: 18661561) ; J Alzheimers Dis. 2011;26 Suppl 3:91-5. (PMID: 21971453) ; J Neural Transm (Vienna). 2015 Nov;122(11):1515-21. (PMID: 26133163) ; Mov Disord. 2006 Sep;21(9):1368-74. (PMID: 16721753) ; Neural Regen Res. 2013 May 15;8(14):1276-85. (PMID: 25206422) ; Mov Disord. 2008 Jan 30;23(2):174-82. (PMID: 17999421) ; Eur J Radiol. 2013 May;82(5):708-18. (PMID: 21937178) ; Eur Neurol. 2015;73(5-6):303-9. (PMID: 25925562) ; Mov Disord. 2009 Aug 15;24(11):1606-12. (PMID: 19526587) ; Expert Rev Neurother. 2012 Jun;12(6):687-96. (PMID: 22650171) ; Curr Opin Neurol. 2002 Aug;15(4):457-60. (PMID: 12151843) ; Parkinsonism Relat Disord. 2011 Mar;17(3):172-6. (PMID: 21236720) ; Neuroimage. 2006 Jul 1;31(3):1116-28. (PMID: 16545965) ; Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S90-2. (PMID: 22166466) ; Crit Rev Biomed Eng. 2016;44(1-2):73-89. (PMID: 27652452) ; Mov Disord. 2018 Oct;33(10):1647-1650. (PMID: 30288794) ; AJNR Am J Neuroradiol. 2008 Oct;29(9):1692-7. (PMID: 18653686) Entry Date(s): Date Created: 20240510 Date Completed: 20240510 Latest Revision: 20240512 Update Code: 20240512 PubMed Central ID: PMC11081548

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Brain structure comparison among Parkinson disease, essential tremor, and healthy controls using 7T MRI.