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Background: Supplementation with leucine-enriched essential amino acids (LEAAs) has shown efficacy in the recovery of muscle injury and activation of muscle synthesis. Muscle function in knee osteoarthritis is a crucial factor for managing pain and preserving ambulatory function. However, the efficacy and safety of LEAAs supplementation in patients with knee osteoarthritis have not been evaluated.

Methods: In this prospective analysis, we evaluated the efficacy and safety of supplementation with 12 g of LEAAs daily for 8 weeks in knee-symptomatic osteoarthritis patients. For assessing the efficacy, clinical pain, calf circumference, and disability were assessed using questionnaires (visual analog scale, Knee Society Score, and 36-item short form survey [SF-36]), laboratory analyses (total protein and albumin), and radiologic study (dual-energy X-ray absorptiometry [DEXA]) for muscle and bone density. To evaluate safety, generalized or localized protein allergic reactions, complete blood count, liver and kidney function, and serum glucose were measured.

Results: Sixty-five participants, categorized into the experimental (n = 32) and control (n = 33) groups, were included in this 8-week trial from March 2022 to July 2022. A significantly higher efficacy was observed in the experimental group than in the control group, as indicated by muscle density in the DEXA scan (P = .001) and SF-36 (P < .001). The safety evaluation revealed no related generalized or local protein allergy. Hematological findings, serum glucose, and kidney and liver toxicity were not significantly different between the groups.

Conclusion: Supplementation with leucine-enriched proteins is safe and efficacious in the improvement of muscle density and quality of life.

Competing Interests: S. Park, S. Kim, S. C. Nam, H. Ahn, and T. Kim have possible conflicts of interest due to their association with the protein manufacturing industry. For the remaining authors, none were declared.

Titel:	The efficacy and safety of leucine-enriched essential amino acids in knee osteoarthritis patients: A randomized controlled trial.
Autor/in / Beteiligte Person:	Park, SJ ; Nam, CH ; Ahn, HS ; Kim, T
Zeitschrift:	Medicine, Jg. 103 (2024-05-10), Heft 19, S. e38168
Veröffentlichung:	Hagerstown, Md : Lippincott Williams & Wilkins, 2024
Medientyp:	academicJournal
ISSN:	1536-5964 (electronic)
DOI:	10.1097/MD.0000000000038168
Schlagwort:	Humans Female Male Middle Aged Prospective Studies Aged Treatment Outcome Pain Measurement Osteoarthritis, Knee drug therapy Leucine therapeutic use Leucine administration & dosage Dietary Supplements Amino Acids, Essential therapeutic use Amino Acids, Essential administration & dosage
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Randomized Controlled Trial Language: English [Medicine (Baltimore)] 2024 May 10; Vol. 103 (19), pp. e38168. MeSH Terms: Osteoarthritis, Knee* / drug therapy ; Leucine* / therapeutic use ; Leucine* / administration & dosage ; Dietary Supplements* ; Amino Acids, Essential* / therapeutic use ; Amino Acids, Essential* / administration & dosage ; Humans ; Female ; Male ; Middle Aged ; Prospective Studies ; Aged ; Treatment Outcome ; Pain Measurement References: Aust J Physiother. 2009;55(3):213. (PMID: 19736686) ; J Nutr. 2019 Feb 1;149(2):210-220. (PMID: 30698812) ; Ann Surg. 1979 Jul;190(1):18-23. (PMID: 464673) ; Int J Rheumatol. 2011;2011:969012. (PMID: 21826146) ; Ann Rheum Dis. 2005 Jun;64(6):906-12. (PMID: 15897310) ; Rheumatology (Oxford). 2018 May 1;57(suppl_4):iv61-iv74. (PMID: 29684218) ; Sci Rep. 2019 Dec 9;9(1):18639. (PMID: 31819096) ; Nutr J. 2016 Jan 05;15:1. (PMID: 26728196) ; J Nutr. 2016 Dec;146(12):2625S-2629S. (PMID: 27934654) ; BMC Musculoskelet Disord. 2011 Jun 02;12:123. (PMID: 21635746) ; Amino Acids. 2020 Sep;52(9):1319-1335. (PMID: 32974749) ; Acta Orthop. 2017 Jun;88(3):255-258. (PMID: 28287004) ; Nutrients. 2017 Jul 26;9(8):. (PMID: 28933742) ; Clin Orthop Relat Res. 2006 May;446:34-9. (PMID: 16672869) ; J Nutr. 2014 Dec;144(12):2002-8. (PMID: 25411034) ; BMC Geriatr. 2013 May 01;13:41. (PMID: 23634646) ; Pain Med. 2012 Jun;13(6):740-53. (PMID: 22621287) ; Front Physiol. 2016 Jun 28;7:265. (PMID: 27445854) ; Ann Intern Med. 1997 Jul 15;127(2):97-104. (PMID: 9230035) ; Arthritis Care Res (Hoboken). 2019 Aug;71(8):1052-1058. (PMID: 30144308) ; Nutrients. 2020 Aug 12;12(8):. (PMID: 32806718) ; Arthritis Res Ther. 2013;15(5):R106. (PMID: 24008023) ; Am Fam Physician. 2011 Jun 1;83(11):1287-92. (PMID: 21661710) ; Phytomedicine. 2004 Nov;11(7-8):567-75. (PMID: 15636169) ; JB JS Open Access. 2018 Jun 04;3(2):e0006. (PMID: 30280129) ; Mod Rheumatol. 2014 Jan;24(1):166-71. (PMID: 24261774) ; Arthritis Rheumatol. 2015 Dec;67(12):3166-73. (PMID: 26315282) ; Acad Radiol. 2016 Jun;23(6):724-9. (PMID: 26976624) ; Am J Clin Nutr. 2014 Jan;99(1):86-95. (PMID: 24257722) ; Clin Orthop Relat Res. 2013 Feb;471(2):600-5. (PMID: 22965258) ; Gac Sanit. 2005 Mar-Apr;19(2):135-50. (PMID: 15860162) ; Am J Physiol Endocrinol Metab. 2015 Jun 15;308(12):E1056-65. (PMID: 25827594) ; J Epidemiol Community Health. 2001 Feb;55(2):132-8. (PMID: 11154253) ; J Bone Joint Surg Am. 2010 Apr;92(4):990-3. (PMID: 20360527) ; Med Sci Sports Exerc. 2010 May;42(5):962-70. (PMID: 19997002) ; Food Funct. 2018 Dec 13;9(12):6526-6534. (PMID: 30475369) ; Rheum Dis Clin North Am. 2011 Feb;37(1):103-18. (PMID: 21220090) ; Cells. 2020 Jan 30;9(2):. (PMID: 32019276) ; Br J Nutr. 2015 Jan 14;113(1):25-34. (PMID: 25234223) ; Regul Toxicol Pharmacol. 2007 Feb;47(1):78-83. (PMID: 16942821) ; J Int Soc Sports Nutr. 2010 Sep 22;7:30. (PMID: 20860817) Substance Nomenclature: GMW67QNF9C (Leucine) ; 0 (Amino Acids, Essential) Entry Date(s): Date Created: 20240510 Date Completed: 20240510 Latest Revision: 20240512 Update Code: 20240512 PubMed Central ID: PMC11081624

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The efficacy and safety of leucine-enriched essential amino acids in knee osteoarthritis patients: A randomized controlled trial.