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Objective: Despite recent attention to cognitive impairment in essential tremor, few studies examine rates of conversion to diagnoses of mild cognitive impairment and dementia. Development of dementia in essential tremor is associated with loss of functional ability and a doubling of mortality rate. This prospective, longitudinal study comprehensively reports the prevalence and incidence of, and the annual rates of conversion to, mild cognitive impairment and dementia in an essential tremor cohort.

Methods: Patients underwent detailed cognitive assessments and were assigned diagnoses of normal cognition, mild cognitive impairment, or dementia. There were 222 patients at baseline (mean age = 79.3 ± 9.7 years), and 177 patients participated in follow-up evaluations at 18, 36, 54, and 72 months (mean years of observation = 5.1 ± 1.7). Data were compared to those of historical controls and Parkinson disease patients.

Results: The cumulative prevalence of dementia and average annual conversion rate of mild cognitive impairment to dementia were 18.5% and 12.2%, nearly three times higher than rates in the general population, and approximately one half the magnitude of those reported for Parkinson disease patients. The cumulative prevalence of mild cognitive impairment (26.6%) was almost double that of the general population, but less than that in Parkinson disease populations.

Interpretation: We present the most complete exposition of the longitudinal trajectory of cognitive impairment in an essential tremor cohort yet presented. The prevalence of and conversion rates to dementia in essential tremor fall between those associated with the natural course of aging and the more pronounced rates observed in Parkinson disease. ANN NEUROL 2024;95:1193-1204.

Titel:	Prevalence of and Annual Conversion Rates to Mild Cognitive Impairment and Dementia: Prospective, Longitudinal Study of an Essential Tremor Cohort.
Autor/in / Beteiligte Person:	Ghanem, A ; Berry, DS ; Burkes, A ; Grill, N ; Hall, TM ; Hart, KA ; Hernandez, NC ; Chapman, S ; Sharma, VD ; Huey, ED ; Cosentino, SA ; Louis, ED
Zeitschrift:	Annals of neurology, Jg. 95 (2024-06-01), Heft 6, S. 1193-1204
Veröffentlichung:	New York, NY : Wiley-Liss ; <i>Original Publication</i>: Boston, Little, Brown., 2024
Medientyp:	academicJournal
ISSN:	1531-8249 (electronic)
DOI:	10.1002/ana.26927
Schlagwort:	Humans Female Male Aged Prevalence Longitudinal Studies Aged, 80 and over Prospective Studies Cohort Studies Essential Tremor epidemiology Cognitive Dysfunction epidemiology Dementia epidemiology Disease Progression
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Ann Neurol] 2024 Jun; Vol. 95 (6), pp. 1193-1204. <i>Date of Electronic Publication: </i>2024 Apr 24. MeSH Terms: Essential Tremor* / epidemiology ; Cognitive Dysfunction* / epidemiology ; Dementia* / epidemiology ; Disease Progression* ; Humans ; Female ; Male ; Aged ; Prevalence ; Longitudinal Studies ; Aged, 80 and over ; Prospective Studies ; Cohort Studies References: Louis ED, McCreary M. How common is essential tremor? Update on the worldwide prevalence of essential tremor. Tremor Hyperkinetic Mov 2021;11:28. ; Louis ED, Ottman R. How many people in the USA have essential tremor? Deriving a population estimate based on epidemiological data. Tremor Hyperkinetic Mov 2014;4:259. ; Louis ED. The primary type of tremor in essential tremor is kinetic rather than postural: cross‐sectional observation of tremor phenomenology in 369 cases. Eur J Neurol 2013;20:725–727. ; Louis ED. 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Prevalence of and Annual Conversion Rates to Mild Cognitive Impairment and Dementia: Prospective, Longitudinal Study of an Essential Tremor Cohort.