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Background: Oral bacterial infections are difficult to treat due to emergence of resistance against antibiotic therapy. Essential oils are considered emerging alternate therapy against bacterial infections and biofilms. We investigated Citrus bergemia flower essential oil against oral pathogens.

Methods: The essential oil was analsyed using Gas Chromatography(GC-MS), in silico investigations, antioxidant, antimicrobial, antibiofilm and antiquorum sensing assays.

Results: Gas Chromatography analysis confirmed presence of 17 compounds including 1,6-Octadien-3-ol,3,7-dimethyl, 48.17%), l-limonene (22.03%) and p-menth-1-ol, 8-ol (7.31%) as major components. In silico analysis showed compliance of all tested major components with Lipinski's rule, Bioavailability and antimicrobial activity using PASS (prediction of activity spectrum of substances). Molecular docking with transcriptional regulators 3QP5, 5OE3, 4B2O and 3Q3D revealed strong interaction of all tested compounds except 1,6-Octadien-3-ol,3,7-dimethyl. All tested compounds presented significant inhibition of DPPH (2,2-diphenyl-1-picrylhydrazyl) (IC 50 0.65 mg/mL), H 2 O 2 (hydrogen peroxide) (63.5%) and high FRAP (ferrous reducing antioxidant power) value (239.01 µg). In antimicrobial screening a significant activity (MIC 0.125 mg/mL) against Bacillus paramycoides and Bacillus chungangensis was observed. Likewise a strong antibiofilm (52.1 - 69.5%) and anti-QS (quorum sensing) (4-16 mm) activity was recorded in a dose dependent manner.

Conclusion: It was therefore concluded that C. bergemia essential oil posess strong antioxidant, antimicrobial and antibiofilm activities against tested oral pathogens.

Titel:	Potential role of Citrus bergamia flower essential oil against oral pathogens.
Autor/in / Beteiligte Person:	Aziz, MI ; Hasan, MM ; Ullah, R ; Bari, A ; Khan, MA ; Hasnain, SZU ; Baloch, R ; Akram, M ; Obaid, A ; Ullah, A ; Abbas, K ; Amin, A
Zeitschrift:	BMC complementary medicine and therapies, Jg. 24 (2024-04-12), Heft 1, S. 157
Veröffentlichung:	London : BioMed Central, [2020]-, 2024
Medientyp:	academicJournal
ISSN:	2662-7671 (electronic)
DOI:	10.1186/s12906-024-04457-7
Schlagwort:	Antioxidants pharmacology Hydrogen Peroxide Molecular Docking Simulation Flowers Oils, Volatile pharmacology Citrus Anti-Infective Agents pharmacology Bacterial Infections
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [BMC Complement Med Ther] 2024 Apr 12; Vol. 24 (1), pp. 157. <i>Date of Electronic Publication: </i>2024 Apr 12. MeSH Terms: Oils, Volatile* / pharmacology ; Citrus* ; Anti-Infective Agents* / pharmacology ; Bacterial Infections* ; Antioxidants / pharmacology ; Hydrogen Peroxide ; Molecular Docking Simulation ; Flowers References: Antibiotics (Basel). 2020 Mar 30;9(4):. (PMID: 32235590) ; Acad Emerg Med. 2019 Jan;26(1):51-59. (PMID: 29869364) ; Curr Drug Targets. 2008 Dec;9(12):1040-7. (PMID: 19128213) ; J Biol Chem. 1994 Mar 18;269(11):8022-8. (PMID: 8132524) ; Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26. (PMID: 11259830) ; J Med Chem. 2022 Nov 10;65(21):14261-14275. (PMID: 36282210) ; J Comput Chem. 2010 Jan 30;31(2):455-61. (PMID: 19499576) ; Front Microbiol. 2017 Apr 24;8:727. (PMID: 28484444) ; PLoS One. 2013 Apr 16;8(4):e61484. (PMID: 23613861) ; Oral Dis. 2024 Mar;30(2):73-79. (PMID: 36680388) ; Front Pharmacol. 2015 Mar 02;6:36. (PMID: 25784877) ; J Bacteriol. 2004 Feb;186(3):692-8. (PMID: 14729694) ; J Food Sci Technol. 2015 Oct;52(10):6777-83. (PMID: 26396429) ; Mol Cell. 2011 Apr 22;42(2):199-209. (PMID: 21504831) ; Food Technol Biotechnol. 2019 Jun;57(2):282-289. (PMID: 31537977) ; J Dent Res. 2015 Oct;94(10):1355-61. (PMID: 26318590) ; Plants (Basel). 2019 Apr 11;8(4):. (PMID: 30978964) ; ChemistryOpen. 2021 Nov;10(11):1142-1149. (PMID: 34806828) ; J Clin Periodontol. 2023 Jan;50(1):71-79. (PMID: 36089889) ; Lipids Health Dis. 2017 Aug 3;16(1):146. (PMID: 28774297) ; J Antimicrob Chemother. 2003 May;51(5):1223-9. (PMID: 12668571) ; Front Microbiol. 2012 Jan 25;3:12. (PMID: 22291693) ; Fitoterapia. 2011 Apr;82(3):309-16. (PMID: 21056640) ; Biochemistry. 2009 Nov 3;48(43):10298-307. (PMID: 19788310) ; J Ethnopharmacol. 2015 Feb 3;160:202-10. (PMID: 25479156) ; Molecules. 2009 Feb 18;14(2):839-49. (PMID: 19255543) ; Integr Food Nutr Metab. 2019 Mar;6(2):. (PMID: 31057945) ; Sci Rep. 2017 Mar 03;7:42717. (PMID: 28256516) ; Plants (Basel). 2021 Dec 22;11(1):. (PMID: 35009027) ; Int J Mol Sci. 2011 Jan 13;12(1):334-52. (PMID: 21339989) ; Pharmazie. 2005 Jul;60(7):498-502. (PMID: 16076074) ; Oxid Med Cell Longev. 2017;2017:3496043. (PMID: 28255425) ; J Agric Food Chem. 1999 Oct;47(10):3954-62. (PMID: 10552749) ; Phytother Res. 2017 Jan;31(1):27-39. (PMID: 27747942) ; Molecules. 2021 Nov 20;26(22):. (PMID: 34834107) ; BMC Complement Altern Med. 2016 Nov 28;16(1):486. (PMID: 27894288) ; PLoS One. 2012;7(11):e50798. (PMID: 23226386) ; ChemMedChem. 2016 Jun 6;11(11):1117-21. (PMID: 27218427) ; Dent Clin North Am. 2017 Apr;61(2):305-318. (PMID: 28317568) ; Pestic Biochem Physiol. 2019 Jul;158:185-200. (PMID: 31378356) ; Antibiotics (Basel). 2021 Dec 08;10(12):. (PMID: 34943716) ; PLoS One. 2014 Sep 26;9(9):e107431. (PMID: 25260046) ; Med Oral Patol Oral Cir Bucal. 2004;9 Suppl:101-7; 92-100. (PMID: 15580140) Grant Information: RSP2024R146 King Saud University Contributed Indexing: Keywords: Aroma; Cell to cell signaling; Drug resistance; In silico analysis; Oxidative stress Substance Nomenclature: 0 (Antioxidants) ; BBX060AN9V (Hydrogen Peroxide) ; 0 (Oils, Volatile) ; 0 (Anti-Infective Agents) Entry Date(s): Date Created: 20240412 Date Completed: 20240415 Latest Revision: 20240425 Update Code: 20240425 PubMed Central ID: PMC11010433

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Potential role of Citrus bergamia flower essential oil against oral pathogens.