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Aim: In this study, it was aimed to examine the antibacterial activity of the essential oil components (EOCs), carvacrol (CAR), cinnamaldehyde (CIN), thymol (TH), alpha pinene (α-PN), eucalyptol (EU), limonene (LIM), and the antibiotics, linezolid (LZD), vancomycin (VAN), gentamicin (GEN), ciprofloxacin (CIP), clindamycin (CLN), and penicillin (PEN) against 50 multidrug resistant Corynebacterium striatum strains, and the synergistic interactions of CAR and CIN with the antibiotics against 10 randomly selected Coryne. striatum strains to explore synergistic interactions to determine if their combined use could enhance antibiotic activity and potentially reduce resistance.

Methods and Results: The activity of the EOCs and the antibiotics against Coryne. striatum strains isolated from clinical specimens, was examined by broth microdilution method. The synergistic interactions of the EOCs with the antibiotics against 10 randomly selected Coryne. striatum strains were determined by checkerboard method. EOCs, CIN, and CAR and antibiotics, LZD, VAN, GEN, CIP, and CLN were detected to have antibacterial activity against Coryne. striatum strains alone and either synergistic interactions were observed in combinations of the antibiotics with EOCs.

Conclusions: All Coryne. striatum strains were determined to be susceptible to VAN and LZD and resistant to GEN, PEN, CIP, and CLN. Synergistic interactions were observed in all combinations of antibiotics tested with CAR and CIN.

Titel:	Synergistic interactions of essential oil components with antibiotics against multidrug-resistant Corynebacterium striatum.
Autor/in / Beteiligte Person:	Yilmaz, U ; Coşkun, AG ; Özel, Y ; Ünlü, M ; Vardar-Ünlü, G
Zeitschrift:	Journal of applied microbiology, Jg. 135 (2024-04-01), Heft 4
Veröffentlichung:	2022- : Oxford : Oxford University Press ; <i>Original Publication</i>: Oxford : Published for the Society for Applied Bacteriology by Blackwell Science, c1997-, 2024
Medientyp:	academicJournal
ISSN:	1365-2672 (electronic)
DOI:	10.1093/jambio/lxae090
Schlagwort:	Cymenes pharmacology Ciprofloxacin pharmacology Gentamicins pharmacology Vancomycin pharmacology Linezolid pharmacology Limonene pharmacology Eucalyptol pharmacology Thymol pharmacology Clindamycin pharmacology Humans Penicillins pharmacology Terpenes pharmacology Cyclohexenes pharmacology Corynebacterium Infections microbiology Anti-Bacterial Agents pharmacology Drug Synergism Corynebacterium drug effects Microbial Sensitivity Tests Oils, Volatile pharmacology Drug Resistance, Multiple, Bacterial drug effects Acrolein analogs & derivatives Acrolein pharmacology Monoterpenes pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Appl Microbiol] 2024 Apr 01; Vol. 135 (4). MeSH Terms: Acrolein* / analogs & derivatives ; Anti-Bacterial Agents / pharmacology ; Drug Synergism* ; Corynebacterium* / drug effects ; Microbial Sensitivity Tests* ; Oils, Volatile* / pharmacology ; Drug Resistance, Multiple, Bacterial* / drug effects ; Acrolein* / pharmacology ; Monoterpenes* / pharmacology ; Cymenes / pharmacology ; Ciprofloxacin / pharmacology ; Gentamicins / pharmacology ; Vancomycin / pharmacology ; Linezolid / pharmacology ; Limonene / pharmacology ; Eucalyptol / pharmacology ; Thymol / pharmacology ; Clindamycin / pharmacology ; Humans ; Penicillins / pharmacology ; Terpenes / pharmacology ; Cyclohexenes / pharmacology ; Corynebacterium Infections / microbiology Grant Information: BAP: 2021-091 Balıkesir University Scientific Research Projects Contributed Indexing: Keywords: Corynebacterium striatum; antibiotics; essential oil components Substance Nomenclature: 0 (Anti-Bacterial Agents) ; 0 (Oils, Volatile) ; 7864XYD3JJ (Acrolein) ; 0 (Monoterpenes) ; SR60A3XG0F (cinnamaldehyde) ; 9B1J4V995Q (carvacrol) ; 0 (Cymenes) ; 5E8K9I0O4U (Ciprofloxacin) ; 0 (Gentamicins) ; 6Q205EH1VU (Vancomycin) ; ISQ9I6J12J (Linezolid) ; 9MC3I34447 (Limonene) ; RV6J6604TK (Eucalyptol) ; 3J50XA376E (Thymol) ; 3U02EL437C (Clindamycin) ; 0 (Penicillins) ; 0 (Terpenes) ; 0 (Cyclohexenes) SCR Organism: Corynebacterium striatum Entry Date(s): Date Created: 20240408 Date Completed: 20240425 Latest Revision: 20240425 Update Code: 20240425

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Synergistic interactions of essential oil components with antibiotics against multidrug-resistant Corynebacterium striatum.