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Gametocyte development of the Plasmodium parasite is a key step for transmission of the parasite. Male and female gametocytes are produced from a subpopulation of asexual blood-stage parasites, but the mechanisms that regulate the differentiation of sexual stages are still under investigation. In this study, we investigated the role of PbARID, a putative subunit of a SWI/SNF chromatin remodeling complex, in transcriptional regulation during the gametocyte development of P. berghei. PbARID expression starts in early gametocytes before the manifestation of male and female-specific features, and disruption of its gene results in the complete loss of gametocytes with detectable male features and the production of abnormal female gametocytes. ChIP-seq analysis of PbARID showed that it forms a complex with gSNF2, an ATPase subunit of the SWI/SNF chromatin remodeling complex, associating with the male cis-regulatory element, TGTCT. Further ChIP-seq of PbARID in gsnf2-knockout parasites revealed an association of PbARID with another cis-regulatory element, TGCACA. RIME and DNA-binding assays suggested that HDP1 is the transcription factor that recruits PbARID to the TGCACA motif. Our results indicated that PbARID could function in two chromatin remodeling events and paly essential roles in both male and female gametocyte development.

Titel:	PbARID-associated chromatin remodeling events are essential for gametocyte development in Plasmodium.
Autor/in / Beteiligte Person:	Nishi, T ; Kaneko, I ; Iwanaga, S ; Yuda, M
Zeitschrift:	Nucleic acids research, Jg. 52 (2024-06-10), Heft 10, S. 5624-5642
Veröffentlichung:	1992- : Oxford : Oxford University Press ; <i>Original Publication</i>: London, Information Retrieval ltd., 2024
Medientyp:	academicJournal
ISSN:	1362-4962 (electronic)
DOI:	10.1093/nar/gkae207
Schlagwort:	Animals Female Male Mice Genotype Sequence Analysis, RNA Chromatin genetics Chromatin metabolism Amino Acid Sequence Sequence Analysis, Protein Phylogeny Transcriptome Genome, Protozoan Chromatin Assembly and Disassembly genetics Plasmodium berghei genetics Plasmodium berghei growth & development Protozoan Proteins genetics Protozoan Proteins metabolism Transcription Factors genetics Transcription Factors metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Nucleic Acids Res] 2024 Jun 10; Vol. 52 (10), pp. 5624-5642. MeSH Terms: Chromatin Assembly and Disassembly* / genetics ; Plasmodium berghei* / genetics ; Plasmodium berghei* / growth & development ; Protozoan Proteins* / genetics ; Protozoan Proteins* / metabolism ; Transcription Factors* / genetics ; Transcription Factors* / metabolism ; Animals ; Female ; Male ; Mice ; Genotype ; Sequence Analysis, RNA ; Chromatin / genetics ; Chromatin / metabolism ; Amino Acid Sequence ; Sequence Analysis, Protein ; Phylogeny ; Transcriptome ; Genome, Protozoan References: Science. 2019 Nov 15;366(6467):838-843. (PMID: 31672915) ; Nucleic Acids Res. 2019 Dec 16;47(22):11574-11588. (PMID: 31728527) ; PLoS Pathog. 2021 Aug 17;17(8):e1009351. (PMID: 34403450) ; Nat Rev Dis Primers. 2017 Aug 03;3:17050. (PMID: 28770814) ; Nat Commun. 2020 Mar 20;11(1):1503. 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(PMID: 33318704) Grant Information: 21K06986 Japan Society for the Promotion of Science Substance Nomenclature: 0 (Protozoan Proteins) ; 0 (Transcription Factors) ; 0 (Chromatin) Entry Date(s): Date Created: 20240330 Date Completed: 20240609 Latest Revision: 20240612 Update Code: 20240612 PubMed Central ID: PMC11162789

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PbARID-associated chromatin remodeling events are essential for gametocyte development in Plasmodium.