Einzeltreffer — DigiBib

Antimicrobial resistance has emerged as a significant threat to public health, prompting novel combinations comprising of natural sources such as essential oil compounds with conventional antibiotics. This study aimed to determine the possible interactions between six essential oil compounds with eight antibiotics/antifungals against six pathogens ( Staphylococcus aureus , Staphylococcus epidermidis , Pseudomonas aeruginosa , Acinetobacter baumannii , Cutibacterium acnes , and Candida albicans ) commonly implicated in skin infections. The minimum inhibitory concentrations (MICs) for the antibiotics and essential oil compounds were evaluated singularly and in combination using the broth microdilution assay. The fractional inhibitory concentrations (FIC) were calculated to determine the interactive profile of the combinations. The synergistic interactions (FIC ≤ 0.5) were further analysed at varying ratios and depicted on isobolograms. The toxicity of the synergistic combinations was determined using the brine shrimp lethality assay. Eight synergistic interactions were identified against the selected Gram-positive and P. aeruginosa pathogens, and the combinations also demonstrated a reduced toxicity. The combination of amoxicillin and eugenol demonstrated the lowest toxicity (LC 50 = 1081 µg/mL) and the highest selectivity index (14.41) when in a 70:30 ratio. This study provides insight into the in vitro antimicrobial interactions of essential oil compounds and conventional antibiotics that can form a basis for newer therapies.

Titel:	Essential Oil Compounds in Combination with Conventional Antibiotics for Dermatology.
Autor/in / Beteiligte Person:	Simbu, S ; Orchard, A ; Vuuren, SV
Zeitschrift:	Molecules (Basel, Switzerland), Jg. 29 (2024-03-08), Heft 6
Veröffentlichung:	Basel, Switzerland : MDPI, c1995-, 2024
Medientyp:	academicJournal
ISSN:	1420-3049 (electronic)
DOI:	10.3390/molecules29061225
Schlagwort:	Anti-Bacterial Agents pharmacology Amoxicillin Microbial Sensitivity Tests Drug Synergism Oils, Volatile pharmacology Dermatology Anti-Infective Agents pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Molecules] 2024 Mar 08; Vol. 29 (6). <i>Date of Electronic Publication: </i>2024 Mar 08. MeSH Terms: Oils, Volatile* / pharmacology ; Dermatology* ; Anti-Infective Agents* / pharmacology ; Anti-Bacterial Agents / pharmacology ; Amoxicillin ; Microbial Sensitivity Tests ; Drug Synergism References: Nat Rev Microbiol. 2022 May;20(5):257-269. (PMID: 34737424) ; Molecules. 2019 May 15;24(10):. (PMID: 31096594) ; Antibiotics (Basel). 2022 Apr 29;11(5):. (PMID: 35625250) ; Molecules. 2012 May 25;17(6):6305-16. (PMID: 22634841) ; Expert Rev Anti Infect Ther. 2006 Apr;4(2):171-5. (PMID: 16597199) ; Planta Med. 2011 Jul;77(11):1168-82. (PMID: 21283954) ; Sci Rep. 2020 Jan 24;10(1):1162. (PMID: 31980703) ; Toxicol Mech Methods. 2021 Oct;31(8):559-565. (PMID: 34112059) ; Microorganisms. 2020 Mar 23;8(3):. (PMID: 32210139) ; Phytomedicine. 2012 Feb 15;19(3-4):236-8. 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(PMID: 21575699) Grant Information: 129672 National Research Foundation Contributed Indexing: Keywords: antimicrobial; minimum inhibitory concentration; selectivity index; skin; synergy; toxicity Substance Nomenclature: 0 (Anti-Bacterial Agents) ; 0 (Oils, Volatile) ; 0 (Anti-Infective Agents) ; 804826J2HU (Amoxicillin) Entry Date(s): Date Created: 20240328 Date Completed: 20240329 Latest Revision: 20240330 Update Code: 20240330 PubMed Central ID: PMC10974782

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Essential Oil Compounds in Combination with Conventional Antibiotics for Dermatology.