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Objective: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, insulin resistance, and hepatic steatosis (HS). Because dietary essential amino acid (EAA) supplementation has been shown to decrease HS in various populations, this study's objective was to determine whether supplementation would decrease HS in PCOS.

Methods: A randomized, double-blind, crossover, placebo-controlled trial was conducted in 21 adolescents with PCOS (BMI 37.3 ± 6.5 kg/m 2 , age 15.6 ± 1.3 years). Liver fat, very low-density lipoprotein (VLDL) lipogenesis, and triacylglycerol (TG) metabolism were measured following each 28-day phase of placebo or EAA.

Results: Compared to placebo, EAA was associated with no difference in body weight (p = 0.673). Two markers of liver health improved: HS was lower (-0.8% absolute, -7.5% relative reduction, p = 0.013), as was plasma aspartate aminotransferase (AST) (-8%, p = 0.004). Plasma TG (-9%, p = 0.015) and VLDL-TG (-21%, p = 0.031) were reduced as well. VLDL-TG palmitate derived from lipogenesis was not different between the phases, nor was insulin sensitivity (p > 0.400 for both). Surprisingly, during the EAA phase, participants reported consuming fewer carbohydrates (p = 0.038) and total sugars (p = 0.046).

Conclusions: Similar to studies in older adults, short-term EAA supplementation in adolescents resulted in significantly lower liver fat, AST, and plasma lipids and thus may prove to be an effective treatment in this population. Additional research is needed to elucidate the mechanisms for these effects.

Titel:	Metabolic effects of an essential amino acid supplement in adolescents with PCOS and obesity.
Autor/in / Beteiligte Person:	Fordham, TM ; Morelli, NS ; Garcia-Reyes, Y ; Ware, MA ; Rahat, H ; Sundararajan, D ; Fuller, KNZ ; Severn, C ; Pyle, L ; Malloy, CR ; Jin, ES ; Parks, EJ ; Wolfe, RR ; Cree, MG
Zeitschrift:	Obesity (Silver Spring, Md.), Jg. 32 (2024-04-01), Heft 4, S. 678-690
Veröffentlichung:	2013- : Malden, MA : John Wiley & Sons ; <i>Original Publication</i>: Silver Spring, MD : NAASO, the Obesity Society, c2006-, 2024
Medientyp:	academicJournal
ISSN:	1930-739X (electronic)
DOI:	10.1002/oby.23988
Schlagwort:	Adolescent Female Humans Insulin Lipoproteins, VLDL Obesity complications Fatty Liver Hyperandrogenism complications Insulin Resistance Polycystic Ovary Syndrome drug therapy Polycystic Ovary Syndrome complications
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Randomized Controlled Trial; Journal Article Language: English [Obesity (Silver Spring)] 2024 Apr; Vol. 32 (4), pp. 678-690. <i>Date of Electronic Publication: </i>2024 Mar 04. MeSH Terms: Fatty Liver* ; Hyperandrogenism* / complications ; Insulin Resistance* ; Polycystic Ovary Syndrome* / drug therapy ; Polycystic Ovary Syndrome* / complications ; Adolescent ; Female ; Humans ; Insulin ; Lipoproteins, VLDL ; Obesity / complications References: Knochenhauer ES, Key TJ, Kahsar‐Miller M, Waggoner W, Boots LR, Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and White women of the southeastern United States: a prospective study. J Clin Endocrinol Metab. 1998;83(9):3078‐3082. ; Legro RS, Arslanian SA, Ehrmann DA, et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. 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Metabolic effects of an essential amino acid supplement in adolescents with PCOS and obesity.