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Background/objectives: A national study was undertaken through the British ophthalmology surveillance unit (BOSU) to determine the incidence, presenting features and management of essential infantile esotropia (EIE) in the UK.

Methods: Data from a prospective national observational study of newly diagnosed EIE presenting to clinicians in the United Kingdom over a 12-month period were collected. Cases with a confirmed diagnosis by a clinician of a constant, non-accommodative esotropia ≥20 prism dioptres (PD), presenting at ≤12 months, with no neurological or ocular abnormalities were identified through BOSU. Follow-up data were collected at 12 months.

Results: A total of 57 cases were reported giving an incidence of EIE of 1 in 12,828 live births. The mean age of diagnosis and intervention were 7.05 ± 2.6 months (range 2-12) and 14.7 ± 4.9 months (range 6.5-28.1), respectively. Management was surgical in 59.6%, botulinum toxin alone in 22.8%, and 17.5% were observed. The preoperative angle of esotropia was smaller in the observation group (P = 0.04). The postoperative angle of esotropia was not statistically significant between botulinum toxin or surgery (P = 0.3), although the age of intervention was earlier in the botulinum group (P = 0.007). Early intervention (before 12 months of age) did not influence the post-intervention motor outcomes between 0 and 10 prism dioptres of esotropia (P = 0.78).

Conclusions: The incidence of EIE in the UK is considerably lower than reported in other population-based studies. The preferred method of treatment was surgical with earlier intervention in those treated with botulinum toxin. An early age of intervention (<12 months) did not influence motor outcomes.

Titel:	The incidence, clinical features, and management of essential infantile esotropia in the United Kingdom. A British Ophthalmology Surveillance Unit (BOSU) study.
Autor/in / Beteiligte Person:	Yeo, DCM ; Davies, R ; Watkins, WJ ; Watts, P
Zeitschrift:	Eye (London, England), Jg. 38 (2024-03-01), Heft 4, S. 680-686
Veröffentlichung:	<2003->: London : Nature Publishing Group ; <i>Original Publication</i>: [London : Ophthalmological Society of the United Kingdom, 1987-, 2024
Medientyp:	academicJournal
ISSN:	1476-5454 (electronic)
DOI:	10.1038/s41433-023-02901-5
Schlagwort:	Humans Infant Incidence Prospective Studies Vision, Binocular Oculomotor Muscles surgery Ophthalmologic Surgical Procedures Treatment Outcome United Kingdom epidemiology Retrospective Studies Esotropia diagnosis Esotropia epidemiology Esotropia therapy Botulinum Toxins, Type A therapeutic use Ophthalmology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Observational Study; Journal Article Language: English [Eye (Lond)] 2024 Mar; Vol. 38 (4), pp. 680-686. <i>Date of Electronic Publication: </i>2024 Feb 02. MeSH Terms: Esotropia* / diagnosis ; Esotropia* / epidemiology ; Esotropia* / therapy ; Botulinum Toxins, Type A* / therapeutic use ; Ophthalmology* ; Humans ; Infant ; Incidence ; Prospective Studies ; Vision, Binocular ; Oculomotor Muscles / surgery ; Ophthalmologic Surgical Procedures ; Treatment Outcome ; United Kingdom / epidemiology ; Retrospective Studies References: Louwagie CR, Diehl NN, Greenberg AE, Mohney BG. Is the incidence of infantile esotropia declining?: a population-based study from Olmsted County, Minnesota, 1965 to 1994. Arch Ophthalmol. 2009;127:200–3. (PMID: 10.1001/archophthalmol.2008.568276294019204240) ; Arora A, Williams B, Arora AK, McNamara R, Yates J, Fielder A. Decreasing strabismus surgery. Br J Ophthalmol. 2005;89:409–12. 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(PMID: 10.1167/iovs.08-183618441299) Substance Nomenclature: EC 3.4.24.69 (Botulinum Toxins, Type A) Entry Date(s): Date Created: 20240201 Date Completed: 20240311 Latest Revision: 20240311 Update Code: 20240311 PubMed Central ID: PMC10920776

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The incidence, clinical features, and management of essential infantile esotropia in the United Kingdom. A British Ophthalmology Surveillance Unit (BOSU) study.