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Objectives: The objective of the current study is to compare the treatment effects of different vitamins on essential hypertension to provide an initial basis for developing evidence-based practices.

Design: Systematic review and network meta-analysis.

Data Sources: Five electronic databases (PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov) were searched from their inception to 25 September 2023.

Outcomes: The primary outcomes were the difference between the intervention group and the control group in changes in office systolic blood pressure (SBP) and office diastolic blood pressure (DBP) from baseline. The secondary outcomes were the difference between the intervention group and the control group in changes in 24-hour mean ambulatory systolic blood pressure (24 hours SBP), 24-hour mean ambulatory diastolic blood pressure (24 hours DBP) and heart rate (HR) from baseline.

Results: A total of 23 studies comparing five vitamins (vitamin B 2 , vitamin C, vitamin D, vitamin E, folic acid) and involving 2218 participants were included. The included trials were all vitamin versus placebo, so the network was star-shaped. Among the five vitamins, only vitamin E was significantly more effective at reducing SBP (mean difference: -14.14 mm Hg, 95% credible intervals: -27.62 to -0.88) than placebo. In addition, no evidence was found that any of the five vitamins influenced DBP, 24 hours SBP, 24 hours DBP, or HR. The dose of vitamins, geographical region and percentage of males (only SBP) might be sources of heterogeneity. Sensitivity and subgroup analysis revealed that the effect of vitamin intervention on blood pressure varies according to different doses of vitamins.

Conclusions: According to the results, vitamin E might be an effective measure to reduce SBP, but more research is needed to validate this finding.

Prospero Registration Number: CRD42022352332.

Competing Interests: Competing interests: None declared.

Titel:	Effect of vitamin B <subscript>2</subscript> , vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis.
Autor/in / Beteiligte Person:	Qi, S ; Luo, X ; Liu, S ; Ling, B ; Si, M ; Jin, H
Zeitschrift:	BMJ open, Jg. 14 (2024-01-30), Heft 1, S. e074511
Veröffentlichung:	[London] : BMJ Publishing Group Ltd, 2011-, 2024
Medientyp:	academicJournal
ISSN:	2044-6055 (electronic)
DOI:	10.1136/bmjopen-2023-074511
Schlagwort:	Adult Male Humans Ascorbic Acid therapeutic use Folic Acid therapeutic use Riboflavin therapeutic use Vitamin E therapeutic use Network Meta-Analysis Vitamins Essential Hypertension drug therapy Blood Pressure Vitamin A Vitamin K Vitamin D therapeutic use Vitamin D pharmacology Hypertension drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Meta-Analysis; Systematic Review; Journal Article; Research Support, Non-U.S. Gov't Language: English [BMJ Open] 2024 Jan 30; Vol. 14 (1), pp. e074511. <i>Date of Electronic Publication: </i>2024 Jan 30. MeSH Terms: Vitamin D* / therapeutic use ; Vitamin D* / pharmacology ; Hypertension* / drug therapy ; Adult ; Male ; Humans ; Ascorbic Acid / therapeutic use ; Folic Acid / therapeutic use ; Riboflavin / therapeutic use ; Vitamin E / therapeutic use ; Network Meta-Analysis ; Vitamins ; Essential Hypertension / drug therapy ; Blood Pressure ; Vitamin A ; Vitamin K References: J Nutr Gerontol Geriatr. 2016 Oct-Dec;35(4):243-252. (PMID: 27897610) ; Eur J Clin Nutr. 2020 Jul;74(7):1091-1099. (PMID: 31827258) ; J Clin Epidemiol. 2019 Apr;108:77-85. (PMID: 30529648) ; BMJ. 2021 Mar 29;372:n71. (PMID: 33782057) ; J Clin Epidemiol. 2021 Nov;139:49-56. (PMID: 34293434) ; JAMA. 2022 Jun 21;327(23):2326-2333. (PMID: 35727271) ; Food Res Int. 2020 Feb;128:108749. (PMID: 31955788) ; N Engl J Med. 2016 Sep 8;375(10):971-9. (PMID: 27602669) ; Blood Press Monit. 2015 Apr;20(2):83-91. (PMID: 25350782) ; JAMA. 2022 Nov 8;328(18):1849-1861. (PMID: 36346411) ; Hypertension. 2013 Jun;61(6):1302-8. (PMID: 23608654) ; Lancet. 2021 Sep 11;398(10304):957-980. (PMID: 34450083) ; Am J Hypertens. 2012 Nov;25(11):1215-22. (PMID: 22854639) ; Health (Irvine Calif). 2014 Jun;6(12):1503-1511. (PMID: 25505940) ; Diabetes Metab Syndr. 2021 Jul-Aug;15(4):102200. (PMID: 34265491) ; Front Genet. 2021 Nov 26;12:698590. (PMID: 34899823) ; Hypertens Res. 2023 May;46(5):1267-1275. (PMID: 36609495) ; J Hum Hypertens. 2019 Jul;33(7):499-507. (PMID: 30846828) ; Int J Vitam Nutr Res. 2002 Oct;72(5):309-14. (PMID: 12463106) ; Front Cardiovasc Med. 2023 Jun 19;10:1182731. (PMID: 37404741) ; Front Nutr. 2022 Mar 10;9:829307. (PMID: 35360696) ; Eur Heart J. 2022 May 7;43(18):1731-1739. (PMID: 34891159) ; JAMA Intern Med. 2013 Oct 14;173(18):1672-9. (PMID: 23939263) ; Am J Hypertens. 1989 Jan;2(1):20-5. (PMID: 2643969) ; Crit Rev Food Sci Nutr. 2023;63(13):1846-1861. (PMID: 34478339) ; Hypertension. 2014 Apr;63(4):706-12. (PMID: 24420547) ; Antioxidants (Basel). 2022 Mar 16;11(3):. (PMID: 35326214) ; Prev Chronic Dis. 2020 Jan 09;17:E03. (PMID: 31922371) ; Clin Sci (Lond). 2008 May;114(10):625-34. (PMID: 17999638) ; Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H528-34. (PMID: 11158948) ; Ann Intern Med. 2015 Jun 2;162(11):777-84. (PMID: 26030634) ; Curr Hypertens Rep. 2020 Jul 15;22(8):57. (PMID: 32671631) ; Blood Press Monit. 2016 Jun;21(3):160-7. (PMID: 26910646) ; Nat Rev Cardiol. 2021 Apr;18(4):251-275. (PMID: 33037326) ; Kidney Blood Press Res. 2016;41(6):721-735. (PMID: 27788510) ; Hypertension. 2015 Jun;65(6):1195-201. (PMID: 25801871) ; Res Synth Methods. 2012 Dec;3(4):285-99. (PMID: 26053422) ; Gerontology. 1994;40(5):268-72. (PMID: 7959083) ; BMJ. 2019 Aug 28;366:l4898. (PMID: 31462531) ; Medicine (Baltimore). 2022 Jan 21;101(3):e28628. (PMID: 35060542) ; Medicine (Baltimore). 2019 May;98(19):e15284. (PMID: 31083159) ; Biomedicines. 2023 Sep 04;11(9):. (PMID: 37760893) ; Antioxidants (Basel). 2020 Dec 03;9(12):. (PMID: 33287462) ; Am J Hypertens. 2000 Jun;13(6 Pt 1):611-6. (PMID: 10912743) ; J Clin Hypertens (Greenwich). 2023 Aug;25(8):689-699. (PMID: 37433173) ; J Chiropr Med. 2009 Mar;8(1):15-24. (PMID: 19646382) ; Isr Med Assoc J. 2004 Dec;6(12):742-6. (PMID: 15609886) ; Hypertension. 2020 Dec;76(6):1709-1716. (PMID: 33131313) ; Nutrients. 2020 May 07;12(5):. (PMID: 32392715) ; PLoS Med. 2020 Apr 3;17(4):e1003082. (PMID: 32243458) ; Cardiovasc Ther. 2020 Apr 29;2020:4940673. (PMID: 32426036) ; Curr Hypertens Rep. 2022 Oct;24(10):445-453. (PMID: 35737199) ; Medicine (Baltimore). 2020 Feb;99(8):e19274. (PMID: 32080138) ; J Clin Hypertens (Greenwich). 2020 Oct;22(10):1867-1873. (PMID: 32951301) ; Am J Clin Nutr. 2012 May;95(5):1079-88. (PMID: 22492364) ; Atherosclerosis. 2014 Jul;235(1):102-9. (PMID: 24942709) ; IUBMB Life. 2019 Apr;71(4):507-515. (PMID: 30779288) ; J Hypertens. 2020 May;38(5):799-812. (PMID: 31977574) ; PLoS One. 2014 Jul 03;9(7):e99682. (PMID: 24992266) ; Circ Res. 2021 Apr 2;128(7):847-863. (PMID: 33793328) ; Hypertens Res. 2022 Dec;45(12):1986-1996. (PMID: 36202982) ; Hypertension. 1999 Oct;34(4 Pt 2):1002-6. (PMID: 10523398) ; BMC Med. 2020 Nov 11;18(1):318. (PMID: 33172445) Contributed Indexing: Keywords: Blood Pressure; Hypertension; NUTRITION & DIETETICS Substance Nomenclature: 1406-16-2 (Vitamin D) ; PQ6CK8PD0R (Ascorbic Acid) ; 935E97BOY8 (Folic Acid) ; TLM2976OFR (Riboflavin) ; 1406-18-4 (Vitamin E) ; 0 (Vitamins) ; 11103-57-4 (Vitamin A) ; 12001-79-5 (Vitamin K) Entry Date(s): Date Created: 20240131 Date Completed: 20240205 Latest Revision: 20240209 Update Code: 20240210 PubMed Central ID: PMC10828875

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Effect of vitamin B <subscript>2</subscript> , vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis.