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Cupressus torulosa is an evergreen tree with a wide distribution in north-western Himalayan region of India. Its needles have long been used in traditional medicine for anti-inflammatory, antimicrobial, and wound-healing properties. This study aimed to scientifically validate the traditional claim of the needles to treat inflammation by evaluating the chemical composition, antioxidant potential, and anti-inflammatory activity of the essential oil extracted from the needles (CTEO) using hydro-distillation. Qualitative and quantitative chemical composition of the CTEO was determined with the aid of GC-MS and GC-FID techniques. The major constituents of the CTEO were terpinen-4-ol (393.8±12.5 μg/mg), totarol (55.0±17.2 μg/mg), and sabinene (43.7±2.8 μg/mg). CTEO exhibited significant antioxidant activity when evaluated using DPPH free radical scavenging and reducing power assays. Furthermore, the CTEO demonstrated good anti-inflammatory behavior in in vitro egg albumin denaturation assay, with an IC 50 of 27.32 μg/mL. In vivo tests using carrageenan-induced paw edema and xylene-induced ear edema in rats showed significant effects at doses of 30 mg/kg for up to 1 hour. The significant discoveries not only support the established assertions about the anti-inflammatory properties of C. torulosa needles but also highlight their potential as a useful resource in the growing herbal, complementary, and alternative medicine sectors.

Titel:	Phytochemistry and Therapeutic Potential of Cupressus torulosa Needles Essential Oil from India.
Autor/in / Beteiligte Person:	Bhalla, P ; Chauhan, K ; Chitme, HR ; Varshney, VK
Zeitschrift:	Chemistry & biodiversity, Jg. 21 (2024-03-01), Heft 3, S. e202301259
Veröffentlichung:	Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004-, 2024
Medientyp:	academicJournal
ISSN:	1612-1880 (electronic)
DOI:	10.1002/cbdv.202301259
Schlagwort:	Rats Animals Anti-Inflammatory Agents pharmacology Anti-Inflammatory Agents therapeutic use Antioxidants pharmacology Antioxidants chemistry Plant Extracts chemistry Edema chemically induced Edema drug therapy Oils, Volatile pharmacology Oils, Volatile therapeutic use Cupressus chemistry Anti-Infective Agents pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Chem Biodivers] 2024 Mar; Vol. 21 (3), pp. e202301259. <i>Date of Electronic Publication: </i>2024 Feb 21. MeSH Terms: Oils, Volatile* / pharmacology ; Oils, Volatile* / therapeutic use ; Cupressus* / chemistry ; Anti-Infective Agents* / pharmacology ; Rats ; Animals ; Anti-Inflammatory Agents / pharmacology ; Anti-Inflammatory Agents / therapeutic use ; Antioxidants / pharmacology ; Antioxidants / chemistry ; Plant Extracts / chemistry ; Edema / chemically induced ; Edema / drug therapy References: F. Bakkali, S. Averbeck, D. Averbeck, M. Idaomar, Food Chem. Toxicol. 2008, 46(2), 446-475. ; N. Basavegowda, K. H. Baek, Biomol. Eng. 2021, 11(9), 1267. ; S. Chouhan, K. Sharma, S. Guleria, Medicine 2017, 4(3), 58. ; G. S. Pérez, S. S. Zavala, M. G. Arias, L. M. Ramos, J. Essent. Oil Res. 2011, 23(5), 38-44. ; O. Elkiran, C. Avsar, A. Veyisoglu, E. Bagci, Journal of Essential Oil Bearing Plants 2023, 1-11. ; D. M. Tit, S. G. Bungau, Antioxidants 2023, 12(2), 383. ; P. Rungqu, O. Oyedeji, M. Gondwe, A. Oyedeji, Molecules 2023, 28(14), 5294. ; S. Dakhlaoui, W. A. Wannes, H. Sari, M. B. Hmida, O. Frouja, H. Limam, S. Tammar, S. Bachkouel, M. B. Jemaa, S. Jallouli, K. Hessini, Journal of Essential Oil Bearing Plants 2022, 25(1), 188-199. ; S. A. Selim, M. E. Adam, S. M. Hassan, A. R. Albalawi, BMC Complementary Altern. Med. 2014, 14, 1-8. ; C. Frezza, D. De Vita, F. Sciubba, C. Toniolo, L. Tomassini, M. Nicoletti, M. Franceschin, M. Guiso, A. Bianco, M. Serafini, S. Foddai, Appl. Sci. 2022, 12(14), 7353. ; A. Farjon, Curtis's Botanical Magazine 2013, 30(3), 166-176. ; D. P. Little, Syst. Bot. 2006, 31(3), 461-480. ; L. Piovetti, E. Gonzalez, A. Diara, Phytochemistry 1980, 19, 2772-2773. ; P. Holmes, The Energetics of Western Herbs, Artemis Press, Boulder, USA, 1989, 792, 567. ; R. Tisserand, T. Balacs, Essential oil safety: a guide for health professionals, Churchill Livingstone, UK, 1995, 28, 31. ; H. Singh, A. Saklani, B. Lal, Econ. Bot. 1990, 44(3), 349-354. ; H. Lohani, A. Kumar, U. Bhandari, S. Z. Haider, S. Singh, N. Chauhan, J. Essent. Oil-Bear. Plants 2014, 17(6), 1257-1267. ; S. Gupta, M. Bhagat, R. Sudan, S. Rajput, K. Rajput, Indian J. Exp. Biol. 2018, 56(4), 252-257. ; R. C. Padalia, R. S. Verma, A. Chauhan, C. S. Chanotiya, J. Essent. Oil Res. 2013, 25(4), 251-256. ; K. Khulbe, U. Verma, P. Pant, Int J Adv Biol Res 2016, 6(2), 259-266. ; S. Joshi, S. C. Sati, P. Kumar, J. Phytopharmacol 2016, 5, 190-200. ; K. A. Bhat, H. S. Viswanath, N. A. Bhat, T. A. Wani, Indian Phytopathol. 2017, 70(4), 463-470. ; S. Joshi, K. Parikshit, P. Prabha, S. C. Sati, The Journal of Phytopharmacology 2018, 7(3), 230-241. ; U. Bhandari, G. Gwari, G. Naik, S. Pant, H. Lohani, Int. J. Pharm. 2015, 6, 27-31. ; R. P. Adams, Identification of essential oil components by gas chromatography/mass spectrometry. 5 online ed. Texensis Publishing, 2017. ; NIST Standard Reference Database Number 69, Eds P. J. Linstrom, W. G. Mallard, National Institute of Standards, Technology, Gaithersburg (MD), 2019. ; V. E. Kovats, Helv. Chim. Acta 1958, 41(7), 1915-1932. ; T. Cachet, H. Brevard, A. Chaintreau, J. Demyttenaere, L. French, K. Gassenmeier, D. Joulain, T. Koenig, H. Leijs, P. Liddle, G. Loesing, M. Marchant, Ph. Merle, K. Saito, C. Schippa, F. Sekiya, T. Smith, Flavour Fragrance J. 2016, 31(3), 191-194. ; M. S. Blois, Nature 1958, 181, 1199-1200. ; S. B. Kedare, R. P. Singh, J. Food Sci. Technol. 2011, 48, 412-422. ; M. Oyaizu, The Japanese journal of nutrition and dietetics 1986, 44(6), 307-315. ; S. Chandra, P. Chatterjee, P. Dey, S. Bhattacharya, Asian Pacific Journal of Tropical Biomedicine 2012, 2(1), S178-S180. ; OECD Test No. 423: Acute Oral toxicity - Acute Toxic Class Method, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris, https://doi.org/10.1787/9789264071001-en. ; C. J. Morris, Inflammation protocols 2003, 115-121. ; C. Wang, J. Sun, H. Li, X. Yang, H, Liu, J. Chen, J. Nat. Med. 2016, 70, 563-570. ; H. Lohani, G. Gwari, H. C. Andola, U. Bhandari, N. Chauhan, Indian J. Pharm. Sci. 2012, 74(3), 278-280. ; N. Y. Marchuk, Ukrainica Bioorganica Acta 2014, 1, 40-43. ; A. Giatropoulos, D. Pitarokili, F. Papaioannou, D. P. Papachristos, G. Koliopoulos, N. Emmanouel, O. Tzakou, A. Michaelakis, Parasitol. Res. 2013, 112, 1113-1123. ; R. A. Malizia, D. A. Cardell, J. S. Molli, S. González, P. E. Guerra, R. J. Grau, J. Essent. Oil Res. 2000, 12(1), 59-63. ; C. F. Souza, M. D. Baldissera, L. D. L. Silva, M. A. Geihs, B. Baldisserotto, Aquaculture 2018, 486, 217-223. ; A. Bernabeu, S. Shapiro, J. Villalaín, Chem. Phys. Lipidss 2002, 119(1-2), 33-39. ; E. Gonzalez-Burgos, M. P. Gómez-Serranillos, Curr. Med. Chem. 2012, 19(31), 5319-5341. ; N. I. Osman, N. J. Sidik, A. Awal, N. A. M. Adam, N. I. Rezali, Journal of Intercultural Ethnopharmacology 2016, 5(4), 343. ; K. Kandikattu, P. B. R. Kumar, R. V. Priya, K. S. Kumar, R. S. B. Rathore, Indian Journal of Research in Pharmacy and Biotechnology 2013, 1(5), 729-731. ; J. B. Perianayagam, S. K. Sharma, K. K. Pillai, J. Ethnopharmacol. 2006, 104(3), 410-414. ; V. B. Liju, K. Jeena, R. Kuttan, Indian J. Pharmacol. 2011, 43(5), 526. ; R. Khanna, K. Bhadoriya, Y. C. Tripathi, V. K. Varshney, J. Ethnopharmacol. 2023, 314, 116578. ; M. N. M. Nogueira, S. G. Aquino, C. Rossa Junior, D. M. P. Spolidório, Inflammation Res. 2014, 63, 769-778. ; H. S. Abdillahi, J. F. Finnie, J. Van Staden, J. Ethnopharmacol. 2011, 136(3), 496-503. ; A. Eidi, S. Oryan, J. Zaringhalam, M. Rad, Pharmaceutical biology 2016, 54(3), 549-554. Grant Information: National Authority CAMPA, Ministry of Environment, Forests & Climate Change, Govt. of India Contributed Indexing: Keywords: Anti-inflammatory activity; Antioxidant activity; Biological activity; Cupressus torulosa; Essential oil; GC-MS Substance Nomenclature: 0 (Oils, Volatile) ; 0 (Anti-Inflammatory Agents) ; 0 (Anti-Infective Agents) ; 0 (Antioxidants) ; 0 (Plant Extracts) Entry Date(s): Date Created: 20231229 Date Completed: 20240318 Latest Revision: 20240318 Update Code: 20240318

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Phytochemistry and Therapeutic Potential of Cupressus torulosa Needles Essential Oil from India.