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Aims: Patients with chronic kidney disease (CKD) are at an increased risk of developing heart failure. The American Heart Association recently released a new metric, Life's Essential 8 (LE8), for health promotion. However, evidence regarding associations between LE8 and heart failure risk among patients with CKD is scarce.

Methods and Results: A total of 16 190 patients with CKD (mean age 55.9 years), free of cardiovascular disease at recruitment from the Kailuan Study, were included. Cardiovascular health was assessed using the LE8 score. Incident heart failure events were ascertained via linkage of electronic health record data. Cox proportional hazards regression models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs). There were 814 (5.0%) patients in the high LE8 criteria, with 13 180 (81.4%) in the moderate, and 2196 (13.6%) in the low LE8 category, respectively. During a median follow-up of 13.7 years, 724 incident heart failure cases were documented. Compared with the low LE8 category, the HRs (95% CIs) for heart failure were 0.58 (0.48, 0.71) for the moderate LE8 category and 0.32 (0.19, 0.54) for the high LE8 category (P for trend <0.001). In addition, the association was stronger in patients aged ≤65 years compared with their older counterparts (P for interaction = 0.01).

Conclusion: Our data showed a strong graded inverse association between the LE8-defined cardiovascular health and the risk of heart failure among patients with CKD. Our findings support the importance of adopting the LE8 among patients with CKD to prevent heart failure.

Competing Interests: Conflict of interest: none declared.

Titel:	Life's Essential 8 and heart failure among patients with chronic kidney disease: the Kailuan Cohort Study.
Autor/in / Beteiligte Person:	Huo, Z ; Huang, Z ; Feng, J ; Li, J ; Chen, S ; Wang, G ; Peng, Y ; Huang, L ; Wu, S ; Gao, X ; Li, Y ; Geng, T
Zeitschrift:	European journal of preventive cardiology, Jg. 31 (2024-05-11), Heft 7, S. 824-831
Veröffentlichung:	2021- : [Oxford] : Oxford University Press ; <i>Original Publication</i>: London : Sage, 2024
Medientyp:	academicJournal
ISSN:	2047-4881 (electronic)
DOI:	10.1093/eurjpc/zwad398
Schlagwort:	Humans Male Female Middle Aged Incidence China epidemiology Risk Assessment Aged Risk Factors Adult Time Factors Prospective Studies Prognosis Heart Failure epidemiology Renal Insufficiency, Chronic epidemiology Renal Insufficiency, Chronic diagnosis Renal Insufficiency, Chronic complications
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Eur J Prev Cardiol] 2024 May 11; Vol. 31 (7), pp. 824-831. MeSH Terms: Heart Failure* / epidemiology ; Renal Insufficiency, Chronic* / epidemiology ; Renal Insufficiency, Chronic* / diagnosis ; Renal Insufficiency, Chronic* / complications ; Humans ; Male ; Female ; Middle Aged ; Incidence ; China / epidemiology ; Risk Assessment ; Aged ; Risk Factors ; Adult ; Time Factors ; Prospective Studies ; Prognosis Comments: Comment in: Eur J Prev Cardiol. 2024 Jan 22;:. (PMID: 38253340) Grant Information: JIF201047Y Startup grant at Fudan University Contributed Indexing: Keywords: Cardiovascular health; Chronic kidney disease; Heart failure; Kailuan Study; Life’s Essential 8 ; Local Abstract: [plain-language-summary] Using the Life’s Essential 8 (LE8) score, released by the American Heart Association for cardiovascular health promotion, this study investigated the relationship between cardiovascular health and the risk of heart failure in patients with chronic kidney disease (CKD) in China.Patients with CKD who had better cardiovascular health, as indicated by higher LE8 scores, had a significantly lower risk of heart failure.A stronger association between better LE8 score and lower risk of heart failure among CKD patients aged ≤65 years was observed, compared with their older counterparts. Entry Date(s): Date Created: 20231219 Date Completed: 20240511 Latest Revision: 20240511 Update Code: 20240511

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Life's Essential 8 and heart failure among patients with chronic kidney disease: the Kailuan Cohort Study.