Einzeltreffer — DigiBib

Changes in the intracellular concentration of free calcium (Ca 2+ ) underpin egg activation and initiation of development in animals and plants. In mammals, the Ca 2+ release is periodical, known as Ca 2+ oscillations, and mediated by the type 1 inositol 1,4,5-trisphosphate receptor (IP 3 R1). Another divalent cation, zinc (Zn 2+ ), increases exponentially during oocyte maturation and is vital for meiotic transitions, arrests, and polyspermy prevention. It is unknown if these pivotal cations interplay during fertilization. Here, using mouse eggs, we showed that basal concentrations of labile Zn 2+ are indispensable for sperm-initiated Ca 2+ oscillations because Zn 2+ -deficient conditions induced by cell-permeable chelators abrogated Ca 2+ responses evoked by fertilization and other physiological and pharmacological agonists. We also found that chemically or genetically generated eggs with lower levels of labile Zn 2+ displayed reduced IP 3 R1 sensitivity and diminished ER Ca 2+ leak despite the stable content of the stores and IP 3 R1 mass. Resupplying Zn 2+ restarted Ca 2+ oscillations, but excessive Zn 2+ prevented and terminated them, hindering IP 3 R1 responsiveness. The findings suggest that a window of Zn 2+ concentrations is required for Ca 2+ responses and IP 3 R1 function in eggs, ensuring optimal response to fertilization and egg activation.

Competing Interests: HA, EL, RF No competing interests declared

Titel:	Zn <superscript>2+</superscript> is essential for Ca <superscript>2+</superscript> oscillations in mouse eggs.
Autor/in / Beteiligte Person:	Akizawa, H ; Lopes, EM ; Fissore, RA
Zeitschrift:	ELife, Jg. 12 (2023-12-15)
Veröffentlichung:	Cambridge, UK : eLife Sciences Publications, Ltd., 2012-, 2023
Medientyp:	academicJournal
ISSN:	2050-084X (electronic)
DOI:	10.7554/eLife.88082
Schlagwort:	Male Animals Mice Oogenesis Fertilization Spermatozoa metabolism Calcium metabolism Calcium Signaling Mammals metabolism Oocytes metabolism Semen metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Elife] 2023 Dec 15; Vol. 12. <i>Date of Electronic Publication: </i>2023 Dec 15. MeSH Terms: Oocytes* / metabolism ; Semen* / metabolism ; Male ; Animals ; Mice ; Oogenesis ; Fertilization ; Spermatozoa / metabolism ; Calcium / metabolism ; Calcium Signaling ; Mammals / metabolism Comments: Update of: bioRxiv. 2023 Nov 08;:. (PMID: 37131581) References: Front Cell Dev Biol. 2018 Apr 03;6:36. (PMID: 29666796) ; Development. 2002 Aug;129(15):3533-44. (PMID: 12117804) ; Biol Reprod. 1999 Jan;60(1):49-57. (PMID: 9858485) ; Sci Rep. 2016 Sep 29;6:34236. (PMID: 27681336) ; Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70. (PMID: 2138778) ; Development. 2006 Nov;133(21):4355-65. (PMID: 17038520) ; Biol Reprod. 2001 May;64(5):1338-49. (PMID: 11319137) ; J Biol Chem. 2003 May 9;278(19):16551-60. (PMID: 12621039) ; Biophys J. 1996 Aug;71(2):1048-56. 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(PMID: 9218795) Grant Information: R01 HD092499 United States HD NICHD NIH HHS Contributed Indexing: Keywords: IP3R1; Ca2+; cell biology; developmental biology; eggs; fertilization; mammals; mouse; oocytes Substance Nomenclature: SY7Q814VUP (Calcium) Entry Date(s): Date Created: 20231215 Date Completed: 20231216 Latest Revision: 20231222 Update Code: 20231222 PubMed Central ID: PMC10723796

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Zn <superscript>2+</superscript> is essential for Ca <superscript>2+</superscript> oscillations in mouse eggs.