Einzeltreffer — DigiBib

Fully grown oocytes remain transcriptionally quiescent, yet many maternal mRNAs are synthesized and retained in growing oocytes. We now know that maternal mRNAs are stored in a structure called the mitochondria-associated ribonucleoprotein domain (MARDO). However, the components and functions of MARDO remain elusive. Here, we found that LSM14B knockout prevents the proper storage and timely clearance of mRNAs (including Cyclin B1, Btg4 and other mRNAs that are translationally activated during meiotic maturation), specifically by disrupting MARDO assembly during oocyte growth and meiotic maturation. With decreased levels of storage and clearance, the LSM14B knockout oocytes failed to enter meiosis II, ultimately resulting in female infertility. Our results demonstrate the function of LSM14B in MARDO assembly, and couple the MARDO with mRNA clearance and oocyte meiotic maturation.

Titel:	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.
Autor/in / Beteiligte Person:	Wan, Y ; Yang, S ; Li, T ; Cai, Y ; Wu, X ; Zhang, M ; Muhammad, T ; Huang, T ; Lv, Y ; Chan, WY ; Lu, G ; Li, J ; Sha, QQ ; Chen, ZJ ; Liu, H
Zeitschrift:	Nucleic acids research, Jg. 51 (2023-11-27), Heft 21, S. 11652-11667
Veröffentlichung:	1992- : Oxford : Oxford University Press ; <i>Original Publication</i>: London, Information Retrieval ltd., 2023
Medientyp:	academicJournal
ISSN:	1362-4962 (electronic)
DOI:	10.1093/nar/gkad919
Schlagwort:	Female Humans Meiosis genetics Oocytes physiology RNA, Messenger genetics Mice, Inbred C57BL Male Animals Mice Oogenesis genetics RNA, Messenger, Stored genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Nucleic Acids Res] 2023 Nov 27; Vol. 51 (21), pp. 11652-11667. MeSH Terms: Oogenesis* / genetics ; RNA, Messenger, Stored* / genetics ; Female ; Humans ; Meiosis / genetics ; Oocytes / physiology ; RNA, Messenger / genetics ; Mice, Inbred C57BL ; Male ; Animals ; Mice References: J Biomed Sci. 2016 Mar 29;23:36. (PMID: 27026099) ; J Cell Sci. 2013 Jul 1;126(Pt 13):2955-64. (PMID: 23659999) ; J Vis Exp. 2017 Jun 19;(124):. (PMID: 28654075) ; Biol Reprod. 2019 Sep 1;101(3):579-590. (PMID: 30715134) ; Nucleic Acids Res. 2021 Jun 4;49(10):5867-5880. (PMID: 34048556) ; Nat Commun. 2018 Dec 7;9(1):5239. (PMID: 30531964) ; Reproduction. 2020 Apr;159(4):R189-R201. (PMID: 31846434) ; EMBO J. 2018 Dec 14;37(24):. (PMID: 30478191) ; Nucleic Acids Res. 2019 Dec 2;47(21):11387-11402. (PMID: 31598710) ; Sci Adv. 2022 Jun 17;8(24):eabl8070. (PMID: 35704569) ; Development. 2019 Dec 2;146(23):. (PMID: 31704793) ; FEBS Lett. 2018 Sep;592(17):3007-3023. (PMID: 29972882) ; Dev Biol. 2001 Apr 15;232(2):400-13. (PMID: 11401401) ; Open Biol. 2016 Sep;6(9):. (PMID: 27605379) ; Int J Biochem Cell Biol. 2009 May;41(5):977-81. (PMID: 18723115) ; J Mol Cell Biol. 2016 Aug;8(4):366-8. (PMID: 27190313) ; Reproduction. 2019 May;157(5):465-474. (PMID: 30817322) ; Am J Hum Genet. 2020 Jul 2;107(1):24-33. (PMID: 32502391) ; RNA. 2012 Sep;18(9):1702-15. (PMID: 22836354) ; Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9127-32. (PMID: 10922068) ; Biol Reprod. 2013 Jan 03;88(1):2. (PMID: 23136301) ; FEBS Lett. 2004 Jul 2;569(1-3):18-26. (PMID: 15225602) ; Acta Biochim Pol. 2015;62(3):613-9. (PMID: 26339800) ; Adv Sci (Weinh). 2023 Jun;10(18):e2300043. (PMID: 37083226) ; Results Probl Cell Differ. 2012;55:69-91. (PMID: 22918801) ; Mol Hum Reprod. 2004 Jan;10(1):1-5. (PMID: 14665700) ; Nucleic Acids Res. 2020 Apr 6;48(6):3257-3276. (PMID: 31970406) ; Nucleic Acids Res. 2019 Jan 10;47(1):328-340. (PMID: 30335155) ; Biol Reprod. 2010 May;82(5):1008-17. (PMID: 20075394) ; Nat Struct Mol Biol. 2016 May;23(5):387-94. (PMID: 27065194) ; RNA. 2006 Apr;12(4):547-54. (PMID: 16484376) ; Science. 2022 Oct 21;378(6617):eabq4835. (PMID: 36264786) ; J Biol Chem. 2006 Dec 29;281(52):40096-106. (PMID: 17074753) ; Cell Cycle. 2009 Sep 1;8(17):2741-7. (PMID: 19717979) ; Biol Reprod. 2019 Nov 21;101(5):878-881. (PMID: 31347666) ; J Mol Cell Biol. 2016 Aug;8(4):369-70. (PMID: 27339058) ; Nat Commun. 2022 Aug 30;13(1):5114. (PMID: 36042231) ; Biochim Biophys Acta. 2015 Nov;1849(11):1363-73. (PMID: 26455898) ; Annu Rev Genet. 2016 Nov 23;50:293-316. (PMID: 27686280) ; Biol Rev Camb Philos Soc. 2023 Jun;98(3):900-930. (PMID: 36718948) ; Nat Rev Mol Cell Biol. 2007 Jan;8(1):9-22. (PMID: 17183357) ; Genes Dev. 1997 Oct 15;11(20):2600-21. (PMID: 9334324) ; Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4539-44. (PMID: 12668760) ; J Reprod Dev. 2017 Aug 19;63(4):383-388. (PMID: 28458300) ; Mol Cell. 2017 Oct 5;68(1):144-157.e5. (PMID: 28965817) ; Nat Commun. 2020 Oct 1;11(1):4917. (PMID: 33004802) Grant Information: 2022YFC2703200 National Key Research and Development Program of China; 31988101 Basic Science Center Program of the NFSC; 2021YFC2700200 National Key Research and Development Program of China; 2019U001 Academic Promotion Programme of Shandong First Medical University; 82101731 National Natural Science Foundation of China; 2020RU001 Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences; 14103418 Research Grants Council of Hong Kong; 2020ZLYS02 Shandong Provincial Key Research and Development Program; 690598 CUHK-SDU Joint Laboratory on Reproductive Genetics of CUHK; 2021ZDSYS16 Major Innovation Projects in Shandong Province; ZR2021JQ27 Science Foundation for Distinguished Yong Scholars of Shandong; tsqn202103192] Taishan Scholars Program for Young Experts of Shandong Province Substance Nomenclature: 0 (RNA, Messenger) ; 0 (RNA, Messenger, Stored) Entry Date(s): Date Created: 20231027 Date Completed: 20231201 Latest Revision: 20231201 Update Code: 20231215 PubMed Central ID: PMC10681746

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LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.