Einzeltreffer — DigiBib

T helper type 9 (Th9) cells play important roles in immune responses by producing interleukin-9 (IL-9). Several transcription factors are responsible for Th9 cell differentiation; however, transcriptional regulation of Th9 cells is not fully understood. Here, it is shown that Id1 is an essential transcriptional regulator of Th9 cell differentiation. Id1 is induced by IL-4 and TGF-β. Id1-deficient naïve CD4 T cells fail to differentiate into Th9 cells, and overexpression of Id1 induce expression of IL-9. Mass spectrometry analysis reveals that Id1 interacts with Tcf3 and Tcf4 in Th9 cells. In addition, RNA-sequencing, chromatin immunoprecipitation, and transient reporter assay reveal that Tcf3 and Tcf4 bind to the promoter region of the Il9 gene to suppress its expression, and that Id1 inhibits their function, leading to Th9 differentiation. Finally, Id1-deficient Th9 cells ameliorate airway inflammation in an animal model of asthma. Thus, Id1 is a transcription factor that plays an essential role in Th9 cell differentiation by inhibiting Tcf3 and Tcf4.

Titel:	Transcription Factor Id1 Plays an Essential Role in Th9 Cell Differentiation by Inhibiting Tcf3 and Tcf4.
Autor/in / Beteiligte Person:	Lee, WH ; Hong, KJ ; Li, HB ; Lee, GR
Zeitschrift:	Advanced science (Weinheim, Baden-Wurttemberg, Germany), Jg. 10 (2023-12-01), Heft 35, S. e2305527
Veröffentlichung:	Weinheim : WILEY-VCH, [2014]-, 2023
Medientyp:	academicJournal
ISSN:	2198-3844 (electronic)
DOI:	10.1002/advs.202305527
Schlagwort:	Animals T-Lymphocytes, Helper-Inducer metabolism Gene Expression Regulation Cell Differentiation physiology Transcription Factors genetics Interleukin-9 genetics Interleukin-9 metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Adv Sci (Weinh)] 2023 Dec; Vol. 10 (35), pp. e2305527. <i>Date of Electronic Publication: </i>2023 Oct 22. MeSH Terms: Transcription Factors* / genetics ; Interleukin-9* / genetics ; Interleukin-9* / metabolism ; Animals ; T-Lymphocytes, Helper-Inducer / metabolism ; Gene Expression Regulation ; Cell Differentiation / physiology References: G. R. Lee, Immune Netw 2023, 23, e4. ; a) P. Licona-Limón, J. Henao-Mejia, A. U. Temann, N. Gagliani, I. Licona-Limón, H. Ishigame, L. Hao, D. R. Herbert, R. A. Flavell, Immunity 2013, 39, 744 ;. ; b) M. H. Kaplan, M. M. Hufford, M. R. Olson, Nat. Rev. Immunol. 2015, 15, 295 ;. ; c) E. Schmitt, T. Bopp, Semin Immunopathol 2017, 39, 5. ; a) V. Staudt, E. Bothur, M. Klein, K. Lingnau, S. Reuter, N. Grebe, B. Gerlitzki, M. Hoffmann, A. Ulges, C. Taube, N. Dehzad, M. Becker, M. Stassen, A. Steinborn, M. Lohoff, H. Schild, E. Schmitt, T. Bopp, Immunity 2010, 33, 192 ;. ; b) C. P. Jones, L. G. Gregory, B. Causton, G. A. Campbell, C. M. Lloyd, J. Allergy Clin. Immunol. 2012, 129, 1000. ; a) Y. Lu, S. Hong, H. Li, J. Park, B. Hong, L. Wang, Y. Zheng, Z. Liu, J. Xu, J. He, J. Yang, J. Qian, Q. Yi, J. Clin. Invest. 2012, 122, 4160;. ; b) R. Purwar, C. Schlapbach, S. Xiao, H. S. Kang, W. Elyaman, X. Jiang, A. M. Jetten, S. J. Khoury, R. C. Fuhlbrigge, V. K. Kuchroo, R. A. Clark, T. S. Kupper, Nat. Med. 2012, 18, 1248. ; M. H. Kaplan, Immunol. Rev. 2013, 252, 104. ; a) M. Veldhoen, C. Uyttenhove, J. Van Snick, H. Helmby, A. Westendorf, J. Buer, B. Martin, C. Wilhelm, B. Stockinger, Nat. Immunol. 2008, 9, 1341;. ; b) R. Goswami, R. Jabeen, R. Yagi, D. Pham, J. Zhu, S. Goenka, M. H. Kaplan, J. Immunol. 2012, 188, 968;. ; c) V. Dardalhon, A. Awasthi, H. Kwon, G. Galileos, W. Gao, R. A. Sobel, M. Mitsdoerffer, T. B. Strom, W. Elyaman, I.-C. Ho, S. Khoury, M. Oukka, V. K. Kuchroo, Nat. Immunol. 2008, 9, 1347. ; a) H.-C. Chang, S. Sehra, R. Goswami, W. Yao, Q. Yu, G. L. Stritesky, R. Jabeen, C. Mckinley, A.-N. Ahyi, L. Han, E. T. Nguyen, M. J. Robertson, N. B. Perumal, R. S. Tepper, S. L. Nutt, M. H. Kaplan, Nat. Immunol. 2010, 11, 527;. ; b) W. Elyaman, R. Bassil, E. M. Bradshaw, W. Orent, Y. Lahoud, B. Zhu, F. Radtke, H. Yagita, S. J. Khoury, Immunity 2012, 36, 623. ; A. Ramming, D. Druzd, J. Leipe, H. Schulze-Koops, A. Skapenko, Blood 2012, 119, 4665. ; R. Goswami, M. H. Kaplan, J. Immunol. 2012, 189, 3026. ; R. Jabeen, R. Goswami, O. Awe, A. Kulkarni, E. T. Nguyen, A. Attenasio, D. Walsh, M. R. Olson, M. H. Kim, R. S. Tepper, J. Sun, C. H. Kim, E. J. Taparowsky, B. Zhou, M. H. Kaplan, J. Clin. Invest. 2013, 123, 4641. ; a) A. Jash, A. Sahoo, G.-C. Kim, C.-S. Chae, J.-S. Hwang, J.-E. Kim, S.-H. Im, J. Biol. Chem. 2012, 287, 15445;. ; b) X. Xiao, S. Balasubramanian, W. Liu, X. Chu, H. Wang, E. J. Taparowsky, Y.-X. Fu, Y. Choi, M. C. Walsh, X. C. Li, Nat. Immunol. 2012, 13, 981. ; S. Koch, A. Graser, H. Mirzakhani, T. Zimmermann, V. O. Melichar, M. Wölfel, D. C. Croteau-Chonka, B. A. Raby, S. T. Weiss, S. Finotto, J. Allergy Clin. Immunol. 2016, 137, 1898. ; a) W. Liao, R. Spolski, P. Li, N. Du, E. E. West, M. Ren, S. Mitra, W. J. Leonard, Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 3508;. ; b) R. Bassil, W. Orent, M. Olah, A. T. Kurdi, M. Frangieh, T. Buttrick, S. J. Khoury, W. Elyaman, J. Immunol. 2014, 193, 198. ; S. Malik, S. Sadhu, S. Elesela, R. P. Pandey, A. S. Chawla, D. Sharma, L. Panda, D. Rathore, B. Ghosh, V. Ahuja, A. Awasthi, Nat. Commun. 2017, 8, 815. ; H. Nakatsukasa, D. Zhang, T. Maruyama, H. Chen, K. Cui, M. Ishikawa, L. Deng, P. Zanvit, E. Tu, W. Jin, B. Abbatiello, N. Goldberg, Q. Chen, L. Sun, K. Zhao, W. Chen, Nat. Immunol. 2015, 16, 1077. ; Y.u Wang, Y. Bi, X.i Chen, C. Li, Y. Li, Z. Zhang, J. Wang, Y. Lu, Q. Yu, H. Su, H. Yang, G. Liu, Immunity 2016, 44, 1337. ; B. Koh, M. M. Hufford, D. Pham, M. R. Olson, T. Wu, R. Jabeen, X. Sun, M. H. Kaplan, J. Immunol. 2016, 197, 2465. ; W. H. Lee, S. W. Jang, H. S. Kim, S. H. Kim, J. I. Heo, G. E. Kim, G. R. Lee, Exp. Mol. Med. 2019, 51, 1. ; S.-A. Park, Y.-J. Lim, W. L. Ku, D. Zhang, K. Cui, L.-Y. Tang, C. Chia, P. Zanvit, Z. Chen, W. Jin, D. Wang, J. Xu, O. Liu, F. Wang, A. Cain, N. Guo, H. Nakatsukasa, C. Wu, Y. E. Zhang, K. Zhao, W. Chen, Nat. Commun. 2022, 13, 6069. ; a) M. H. Kaplan, Semin. Immunopathol. 2017, 39, 11;. ; b) S. Malik, A. Awasthi, Front Immunol. 2018, 9, 995. ; a) J. D. Norton, R. W. Deed, G. Craggs, F. Sablitzky, Trends Cell Biol. 1998, 8, 58;. ; b) J. Ke, R. Wu, Y. Chen, M. L. Abba, Am. J. Transl. Res. 2018, 10, 3887;. ; c) F. Ling, B. Kang, X. H. Sun, Curr. Top. Dev. Biol. 2014, 110, 189;. ; d) R. Benezra, R. L. Davis, D. Lockshon, D. L. Turner, H. Weintraub, Cell 1990, 61, 49. ; S.-M. Hwang, S.-H. Im, D. Rudra, Front Immunol 2022, 13, 964581. ; a) A. Lazorchak, M. E. Jones, Y. Zhuang, Trends Immunol. 2005, 26, 334;. ; b) A. Voronova, D. Baltimore, Proc. Natl. Acad. Sci. U. S. A. 1990, 87, 4722. ; a) S. R. Sloan, C.-P. Shen, R. Mccarrick-Walmsley, T. Kadesch, Mol. Cell. Biol. 1996, 16, 6900;. ; b) S. Sawada, D. R. Littman, Mol. Cell. Biol. 1993, 13, 5620;. ; c) G. Bain, S. Gruenwald, C. Murre, Mol. Cell. Biol. 1993, 13, 3522;. ; d) C.-P. Shen, T. Kadesch, Mol. Cell. Biol. 1995, 15, 4518;. ; e) J. K. Ghosh, W. J. Romanow, C. Murre, J. Exp. Med. 2001, 193, 769;. ; f) J. Jia, M. Dai, Y. Zhuang, Eur. J. Immunol. 2008, 38, 2806;. ; g) A. W. Langerak, I. L. M. Wolvers-Tettero, E. J. Van Gastel-Mol, M. E. C. M. Oud, J. J. M. Van Dongen, Blood 2001, 98, 2456. ; a) D. Kim, X.-C. Peng, X.-H. Sun, Mol. Cell. Biol. 1999, 19, 8240;. ; b) S. W. Cochrane, Y. Zhao, S. Perry, T. Urbaniak, X.-H. Sun, Cell Mol. Immunol. 2011, 8, 41;. ; c) H.-C. Wang, S. S. Perry, X.-H. Sun, Mol. Cell. Biol. 2009, 29, 4640;. ; d) X. Sun, Cell 1994, 79, 893;. ; e) M. A. Morrow, E. W. Mayer, C. A. Perez, M. Adlam, G. Siu, Mol. Immunol. 1999, 36, 491. ; S. W. Jang, S. S. Hwang, H. S. Kim, M. K. Kim, W. H. Lee, S. U. Hwang, J. Gwak, S. K. Yew, R. A. Flavell, G. R. Lee, Proc. Natl. Acad. Sci. U. S. A. 2019, 116, 25790. ; N. B. Perumal, M. H. Kaplan, Trends Immunol. 2011, 32, 146. ; P. J. Barnes, J. Clin. Invest. 2008, 118, 3546. ; C. Murre, Nat. Immunol. 2005, 6, 1079. ; F. Annunziato, C. Romagnani, S. Romagnani, J. Allergy Clin. Immunol. 2015, 135, 626. ; E. L. Pearce, A. C. Mullen, G. I. A. Martins, C. M. Krawczyk, A. S. Hutchins, V. P. Zediak, M. Banica, C. B. Dicioccio, D. A. Gross, C.-A. Mao, H. Shen, N. Cereb, S. Y. Yang, T. Lindsten, J. Rossant, C. A. Hunter, S. L. Reiner, Science 2003, 302, 1041. ; Y. Lu, Q. Wang, G. Xue, E. Bi, X. Ma, A. Wang, J. Qian, C. Dong, Q. Yi, Cancer Cell 2018, 33, 1048. ; G. Bain, C. B. Cravatt, C. Loomans, J. Alberola-Ila, S. M. Hedrick, C. Murre, Nat. Immunol. 2001, 2, 165. ; I. Engel, C. Johns, G. Bain, R. R. Rivera, C. Murre, J. Exp. Med. 2001, 194, 733. Grant Information: NRF-2021K2A9A2A06048161 National Research Foundation of Korea; NRF-2022R1A2B5B03001840 National Research Foundation of Korea; NRF-2022R1A4A5032688 National Research Foundation of Korea; NRF-2020R1A6A3A13074208 National Research Foundation of Korea Contributed Indexing: Keywords: Id1; Tcf3; Tcf4; Th9 cell; differentiation; transcriptional regulation Substance Nomenclature: 0 (Transcription Factors) ; 0 (Interleukin-9) Entry Date(s): Date Created: 20231022 Date Completed: 20231218 Latest Revision: 20240225 Update Code: 20240226 PubMed Central ID: PMC10724384

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Transcription Factor Id1 Plays an Essential Role in Th9 Cell Differentiation by Inhibiting Tcf3 and Tcf4.